Dimethyl sulfoxide

Toxicity to birds

Administrative data

Endpoint:

short-term toxicity to birds: acute oral toxicity test

Type of information:

other: publication

Remarks:

publication

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Justification for type of information:

The need for testing should be carrefully considered taking into account the large mammalian dataset that is available for DMSO. Moreover based on the fact that DMSO is neither bioaccumulative nor toxic, no reprotoxicity effects to birds is expected.

Data source

Reference

Reference Type:

publication

Title:

The acute oral toxicity, repellency and hazard potential of 998 chemicals to one or more species of wild and domestic birds

Author:

Schafer EW Jr, Bowles WA Jr and Hurlbut J

Year:

1983

Bibliographic source:

Arch. Environm. Contam. Toxicol., 12, 355-382

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Wild-trapped birds were preconditioned to captivity for 2 to 6 weeks and were usually dosed by gavage with solutions or suspensions of the test chemical in propylene glycol, according to methods described by DeCino et al. (1966), Schafer (1972), and Schafer et al. (1967). Other oral dosing methods were occasionally used (pellets, gelatin capsules) (Schafer, 1972). LD values were calculated by the method of Thompson (1948), Thompson and Weil (1952), and Weil (1952). Repellency tests were conducted by the methods of Starr et al. (1964) and Schafer and Brunton (1971), and R50's (analogous to LD50 s) were calculated either by the method of Litchfield and Wilcoxin (1949) or Thompson and Weil (1952).

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Dimethyl sulfoxide

EC Number:

200-664-3

EC Name:

Dimethyl sulfoxide

Cas Number:

67-68-5

Molecular formula:

C2H6OS

IUPAC Name:

dimethyl sulfoxide

Test organisms

Test organisms (species):

other: other avian

Study design

Details on test conditions:

Method: wild-trapped birds were preconditionned to captivity for 2 to 6 weeks and were usually dosed by gavage with solutions or suspensions of the test chemical in propylene glycol, according to methods described by DeCino et al (1966), Schafer (1972) and Schafer et al (1967).

LD50 values were calculated by the method of Thompson (1948), Thompson and Weil (1952) and Weil (1952).
Repellency tests were conducted by the methods of Starr et al. (1964) and Schafer and Brunton (1971), and R50's were calculated either by the method of Litchfield and Wilconxin
(1949) or Thompson and weil (1952).

Bird species: Agelaius phoeniceus (Red-winged blackbird).

Results and discussion

Effect levels

Duration (if not single dose):

18 h

Dose descriptor:

LD50

Effect level:

100 mg/kg bw

Basis for effect:

mortality