Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 220-688-8 | CAS number: 2867-47-2
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
For 2-dimethylaminoethyl methacrylate, a GLP OECD Guideline 204 study on prolonged toxicity to fish is reported. After 14 days of exposure in a semi-static system a LC50 of 5.26 mg/L was measured. The LC0 after 14 days was determined at 2.96 mg/L. However, according to Annex IX long-term toxicity tests on fish shall provide information about one of the following parameters: a) early-life stage toxicity; b) short-term toxicity on embryo and sac-fry stages or c) juvenile growth inhibition. Thus, the present prolonged study cannot be taken into account for a long-term toxicity assessment; therefore, the result of this study can just be used for a pre-evaluation of the long-term toxicity of the test substance. Furthermore, analytical monitoring showed that a major part of the test substance was degraded within 24 hours. Investigations on abiotic degradation showed that over time the substance will hydrolyse under environmental conditions into methacrylic acid (CAS# 79-41-4) and 2-dimethylamino ethanol (CAS# 108-01-0). Therefore, the mortality was probably caused by degradation products too. An investigation on long-term toxicity is just reported for methacrylic acid. The result of this OECD Guideline 210 study showed a NOEC of 10 mg/L.
According to Annex I of this regulation, the chemical safety assessment triggers further action when the substance or the preparation meets the criteria for classification as dangerous according to Directive 67/548/EEC or Directive 1999/45/EC or is assessed to be a PBT or vPvB.
The hazard assessment of 2-dimethylaminoethyl methacrylate reveals neither a need to classify the substance as dangerous to the environment, nor is it a PBT or vPvB substance, nor are there any further indications that the substance may be hazardous to the environment. Therefore, and for reasons of animal welfare, a long-term toxicity study in fish is not provided.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
