Registration Dossier
Registration Dossier
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EC number: 200-262-8 | CAS number: 56-23-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: A scientifically sound study, but no individual data, limited methodological information.
Data source
Reference
- Reference Type:
- publication
- Title:
- Pouvoir irritant des principaux solvants chlorés aliphatiques sur la peau et les muqueuses oculaires du lapin
- Author:
- Duprat P, Delsaut L, Gradiski D.
- Year:
- 1 976
- Bibliographic source:
- Eur J Toxicol Environ Hyg., vol. 9, no. 3, p. 171-7
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - application of CTC and other chlorinated solvents to the skin of rabbits
- at day 3 histologic examinations of the treated skin regions
- a non-discribed ranking system for skin lesions (differentiating between erythema and edema) was used to classify the skin lesions macroscopically - GLP compliance:
- no
Test material
- Reference substance name:
- Carbon tetrachloride
- EC Number:
- 200-262-8
- EC Name:
- Carbon tetrachloride
- Cas Number:
- 56-23-5
- Molecular formula:
- CCl4
- IUPAC Name:
- tetrachloromethane
- Details on test material:
- - Name of test material (as cited in study report): tetrachlorure de carbone
- Analytical purity: > 99.5 %
- Lot/batch No.: not reported
- Supplier: Flucka
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: New Zealand
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: not reported
- Age at study initiation: not reported
- Weight at study initiation: 2.4 - 3.0 Kg
- Housing: not reported
- Diet (e.g. ad libitum): not reported
- Water (e.g. ad libitum): not reported
- Acclimation period: not reported
ENVIRONMENTAL CONDITIONS
- Temperature (°C): not reported
- Humidity (%): not reported
- Air changes (per hr): not reported
- Photoperiod (hrs dark / hrs light):not reported
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): very likely 0.5 mL (methods not detailed, only referenced to other publication)
- Concentration (if solution): unclear
- Purity > 99.5 %
VEHICLE
- not reported - Duration of treatment / exposure:
- 24 h
- Observation period:
- 72 h, observations at 24, 48 and 72 h post treatment
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure:
- % coverage:
- Type of wrap if used:
REMOVAL OF TEST SUBSTANCE
- Washing (if done):
- Time after start of exposure:
SCORING SYSTEM: Draize scoring system
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: I.I.C.P (very likely: primary skin irritation index)
- Basis:
- mean
- Time point:
- other: 24 and 72 h
- Score:
- 4.2
- Reversibility:
- fully reversible within: 2 weeks or less
- Irritation parameter:
- erythema score
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
- Irritation parameter:
- edema score
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
Any other information on results incl. tables
- the authors classify the skin irritation potency of CTC as medium in ranking comprising the stages: non irritating, almost non irritating, medium irritant and severely irritant.
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The present publication (Duprat 1976) states CTC to be medium irritating to the skin of rabbits after single application.
- Executive summary:
Individual data from different time points of observation are not presented, so a clear classification according to OECD GHS is not possible.
The publication is a survey report on the irritative potential of different chlorinated solvents. Rabbits were dermaly exposed with CTC (and other solvents) and the skin reaction was observed macroscopically as well as microscopically and scored by an undisclosed scoring system (very likely the Draize score system). Observation periods and dosing also remains unclear.
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