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EC number: 270-112-4 | CAS number: 68411-27-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14. Dec. 1978 - 06. Feb. 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Test type:
- other: equivalent to standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Benzoic acid, C12-15-alkyl esters
- EC Number:
- 270-112-4
- EC Name:
- Benzoic acid, C12-15-alkyl esters
- Cas Number:
- 68411-27-8
- Molecular formula:
- C19-22 H30-36 O2
- IUPAC Name:
- Benzoic acid, C12-15-alkyl esters
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- female, body weight at study start: 1.5 - 1.66 kg
male, body weight at study start: 1.51 - 1.87 kg
standard laboratory conditions
food and water ad libitum
Administration / exposure
- Type of coverage:
- other: trunk of each animal encased in a sleeve of plasticised material
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The animals were prepared by clipping the skin of the trunk free of hair. One-half of the animals were further prepared by introducing epidermal abrasions over the clipped skin surface, thus enhancing penetrability of the test material throug the stratum corneum.
Following the exposure period the sleeve was removed and the skin sites gently cleansed. - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observation after 1, 3, 6, 24 hours on the 1st day and daily thereafter; weighing at study start and study end
- Other examinations performed: body weight and clinical signs - Statistics:
- Limit test
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- One dead animal was observed.
- Clinical signs:
- other: No clinical signs were observed.
- Gross pathology:
- not performed
Any other information on results incl. tables
Dosage (mg/KG) |
Sex |
# dead /# dosed |
% |
2000 |
3 M : 3 F |
1/3 : 0/3 |
17 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute dermal lethal dose (LD50) of the test material in albino rabbits was found to be greater than 2000 mg/kg bodyweight. The test material does not meet the criteria for classification and will not require labelling for dermal toxicity in accordance with EU labelling regulations Commission Directive 2001/59/EC.for classification and labelling of dangerous substances and preparations.
- Executive summary:
The study was performed to assess the acute dermal toxicity of the test material in albino rabbits.
A group of six animals (3 males and 3 females) was given a single, 24-hour dermal application of undiluted test material to intact and abraded skin at a dose level of 2000 mg/kg bodyweight. Clinical signs and bodyweight development were monitored during the study.
Mortality: There was one dead animal.
Clinical Observations: There were no signs of systemic toxicity.
Dermal Irritation: There were no signs of dermal irritation.
Bodyweight: 3 animals showed expected gains in bodyweight and the other 3 animals showed body weight loss over the study period.
Conclusion: The acute dermal lethal dose (LD50) of the test material in albino rabbits was found to be greater than 2000 mg/kg bodyweight.
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