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Diss Factsheets
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EC number: 226-218-8 | CAS number: 5329-14-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1942
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Although the study report in a peer-reviewed journal fulfilled scientific principles, some deviations (as expected) from OECD guideline developed 40 years later are apparent, mainly consisting of lack of experimental details.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Studies on the Physiological Effects of Sulfamic Acid and Ammonium Sulfamate
- Author:
- A.M. Ambrose
- Year:
- 1 943
- Bibliographic source:
- The Journal of industrial hygiene and toxicology 25:26-28
- Report date:
- 1942
Materials and methods
- Principles of method if other than guideline:
- 4 doses (0.1, 0.2, 0.4 and 0.8 g/kg bw sulfamic acid) were tested for acute oral toxicity by intraperitonal injection. Representative numbers of animals were used per dose group. Sulfamic acid was applied as 4% aqueous solution having a pH of 0.82, measured electrometrically.
- GLP compliance:
- no
- Remarks:
- pre-dates GLP requirements
- Limit test:
- no
Test material
- Reference substance name:
- Sulphamidic acid
- EC Number:
- 226-218-8
- EC Name:
- Sulphamidic acid
- Cas Number:
- 5329-14-6
- Molecular formula:
- H3NO3S
- IUPAC Name:
- sulfamic acid
- Test material form:
- solid: particulate/powder
- Details on test material:
- sulphamidic acid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: reported as white rat, no strain details provided
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Remarks:
- 4% aqueous solution, pH 0.82
- Details on exposure:
- Male white rats weighing 80 - 100 grams were used
- Doses:
- 0.1, 0.2, 0.4 and 0.8 g sulfamic acid/kg bw
- No. of animals per sex per dose:
- 5 animals per dose group
- Control animals:
- no
- Details on study design:
- All doses were administered in terms of sulfamic acid per kilogram of body weight
- Statistics:
- no statistics applied
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- < 100 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Mortality was observed in all dose groups applied being greater 50%.
100 mg/kg bw: 4/5 dead
200 mg/kg bw: 5/5 dead
400 mg/kg bw: 3/5 dead
800 mg/kg bw: 5/5 dead - Clinical signs:
- The author states "Sulfamic acid after intraperitoneal injection produced no toxic symptoms, although death occured on all dose levels 4 to 72 hours after adminstration."
- Body weight:
- 80 - 100 gram per rat, no effects on body weight development were reported
- Gross pathology:
- not performed in the acute study but in a chronic study, also reported in the article, histopathological examination failed to reveal and changes that could be ascribed to sulfamic acid exposure.
Applicant's summary and conclusion
- Conclusions:
- Sulfamic acid showed high systemic toxicity when applied intraperitoneal. When comparing to the effects seen in the oral study, described in the publication, the mortality seen in the i.p. study may be attributable to the very low pH (0.82) of the 4% aqueous solution injected.
- Executive summary:
In this published study acute intraperitoneal toxicity to rats was investigated up to a maximum dose of 800 mg/kg bw. Mortality > 50% occured at all doses (100, 200, 400 and 800 mg/kg bw). The animals produced no toxic symptoms, although death occured at all dose groups after 4 - 72 hours of exposure (i.p.). Therefore, no LD50 was reported. When comparing to the effects seen in the oral study, described in the same publication, the mortality seen in the i.p. study may be attributable to the very low pH (0.82) of the 4% aqueous solution injected. This is also supported by findings when ammonium sulfamate was applied (reported in the same study) which in 4% aqueous solution has a pH of 4.82 and only caused mortality at 800 mg/kg bw (6 out of 10 animals) when applied by intraperitoneal injection (no mortality at 100, 200 and 400 mg/kg bw).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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