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Diss Factsheets
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EC number: 226-218-8 | CAS number: 5329-14-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
Description of key information
The n-octanol/water partitioning coefficient is not relevant for inorganic substances such as sulphamidic acid. Given the very high solubility in water, a logKow of 0 is proposed to enable the interface to Chesar (in secondary literature an experimental log Kow of 0.1 is reported referenced as Bell EB (1983), but this reference could not be found in public libraries). Nevertheless, this value is cited in the EPI Suite model referenced to “E. B. Bell in Kirk-Othmer Encyclopedia of Chemical Technology vol. 21 (Wiley-Interscience, New York, 3rd ed., 1983) pp 949-960”, but therein experimental details are also very limited.
The EPI Suite (US EPA) Version 4.1 model KOWWIN v1.68 (September 2010) estimated the log Kow to be -4.3438. However, it must be considered that inorganic substances such as sulphamidic acid are not within the training data set and also outside the applicability domain of the model. Nevertheless, it should be noted that for phenyl sulfamide (exp. log Kow 0.40 and Kowwin estimate 0.47) and phenethyl sulfamide (exp. log Kow 0.81 and Kowwin estimate 0.87), the correlation is good, although these are sulfamides.
Considering however, that Benzenesulfonic acid, 4-amino- (exp. log Kow -2.16, Okamoto, H. et al. 1991 and Kowwin estimate -2.08) and Benzenesulfonic acid, 3-NH2, Na salt (exp. log Kow -3.40, Sangster et al. 1994 and Kowwin estimate -3.87) were part of the model validation set, the estimated value for sulphamidic acid does get some weight.
Further support for a negative log Kow value is also provided by solubility data, reported in Kirk-Othmer Encyclopedia of Chemical Technology. 3rd ed., Volumes 1-26. New York, NY: John Wiley and Sons, 1978-1984, reporting a water solubility of sulphamidic acid being 17.57 wt% in water at 20 °C (consistent with 181.4 g/L at 20 °C exp. determined, Muckove 2010, see this dossier), but only 0.0412 wt% in methanol and 0.0167 wt% in ethanol (at 25 °C). As polarity with incresing chain length of alcohols does decrease the solubility in n-octanol is expected being much lower than 0.01 wt%. As a result following a worst case estimate the log Kow is log 0.01/17.57 = -3.25, supporting the estimate derived by Kowwin QSAR method.
However, the conclusion is clear that sulphamidic acid is not having the potential to bioaccumulate, and although a strongly negative log Kow value appears appropriate, for hazard and risk assessment a log Kow value of 0 is used as very conservative approach.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 0
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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