Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 918-811-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute Oral LD50 = 3492 mg/Kg in rats (OECD TG 401)
Acute Dermal LD50 >3160 mg/Kg in rabbits (OECD TG 402)
Acute Inhalation LC50 >6193 mg/m3 in rats (OECD TG 403)
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given: comparable to guidelines/standards.
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 2 male and 2 female rats dosed with 1, 2, 4, or 8 ml/kg of test substance via oral gavage.
- GLP compliance:
- no
- Remarks:
- prior to GLP
- Test type:
- acute toxic class method
- Limit test:
- yes
- Species:
- rat
- Strain:
- other: Charles River CD
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 12 weeks
- Fasting period before study: overnight
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum - Route of administration:
- oral: gavage
- Doses:
- 1, 2, 4, 8 ml/kg
- No. of animals per sex per dose:
- 2
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 9 days
- Frequency of observations and weighing: daily
- Other examinations performed: clinical signs - Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 8 mL/kg bw
- Remarks on result:
- other: (~6984) mg/kg/bw)
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 4 mL/kg bw
- Remarks on result:
- other: (~3492 mg/kg/bw)
- Mortality:
- One female at the 4 ml/kg dosage died on day 7 of the study. The two females given dosages of 8 ml/kg died on day 7 of the study. No males at any dosage level died during the study.
- Clinical signs:
- other: One female from the 8 ml/kg dosage group became ataxic on day 4, a condition that persisted until the death of the animal on day 7.
- Interpretation of results:
- other: Not classified
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 for female rats was 4 ml/kg bw. The LD50 for male rats was > 8 ml/kg (6984 mg/kg/bw). Given the relative density of 0.873 g/ml for the test substance, the LD50 for female rats is equivalent to 3492 mg/kg bw, at which level the test substance is considered not classifiable.
- Executive summary:
This study was conducted to determine the acute oral toxicity of Hydrocarbons, C9, aromatics to rats. 2 male and 2 female rats dosed with 1, 2, 4, or 8 ml/kg of test substance via oral gavage. One female rat in the 4 ml/kg exposure group died, and both females in the 8 ml/kg exposure group died after showing signs of lethargy and ataxia. None of the male rats in the study died. The LD50 for female rats is then 4 ml/kg. The LD50 for male rats is > 8 ml/kg (6984 mg/kg bw). According to EU GHS guidelines, the test substance is not classified as being toxic.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 492 mg/kg bw
- Quality of whole database:
- One key read across study available for assessment.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1996/02/01-1996/02/15
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Equivalent or similar to OECD Guideline 403. GLP.
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- 5 animals used per species (not 10); dry air stream used to generate vapors so no particulate analysis was done
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- other: Crl: CDBR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories Inc.
- Sex: Male (5), Female (5) for each species
- Age at study initiation: 7 weeks
- Weight at study initiation: male 214-242g, female 170-214g
- Housing: Single housed
- Diet (e.g. ad libitum): PMI Feeds, Inc. Certified Rodent Diet #5002 ad libitum during nonexposure period; withheld during exposure
- Water (e.g. ad libitum): automatic watering system, ad libitum
- Acclimation period: 14 d and animals were examined once a day for viability
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 68-76
- Humidity (%): 40-70
- Photoperiod (hrs dark / hrs light): 12/12 - Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- The test material was heated to 137ºC to generate the vapor and resulting vapors were mixed with room air as both were drawn up through the generator and into the exposure chamber.
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- a calibrated infrared vapor analyzer
- Duration of exposure:
- 4 h
- Concentrations:
- Exposure Concentration (average actual): 6193 mg/m³
Exposure Concentration (nominal): 6528 mg/m³
Chamber size: 150 l
ATM pressure: slightly negative pressure to the room
Temperature: 25 deg C
Air flow rate: 30 (L/min) - No. of animals per sex per dose:
- Male (5), Female (5) for each species
- Control animals:
- no
- Details on study design:
- The animals were individually housed in a 150l stainless steel whole body inhalation chamber that was under a slight negative pressure to the room and had an air flow of 30 (l/min). The exposure was 4 hrs plus equilibration time (~23 min) and air flow, temperature, and humidity were continuously monitored. Animals were observed for mortality and obvious toxic signs at 15 min intervals for the first hour of exposure and then once each hour until the termination of the exposure. Body weights for each animal were recorded prior to exposure and on days 7 and 14. A gross necropsy was performed on every animal.
- Statistics:
- Mean and standard deviation of body weight and body weight change by group and sex.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 6 193 mg/m³ air (analytical)
- Remarks on result:
- other: Concentration tested was the maximally attainable vapor concentration.
- Mortality:
- None
- Clinical signs:
- other:
- Body weight:
- All animals gained body weight at the 7 and 14 day observation periods.
- Gross pathology:
- Necropsy examinations performed on all animals at the end of the observational period did not reveal any gross pathological alterations.
- Interpretation of results:
- other: not classifiable
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The LC50 was > 6193 mg/m³ (>6.193 mg/l) air. Based on the LC50 and other data, test substance MRD-95-374 is not classified under either the EU GHS guidelines or under the EU dangerous substances and preparations guidelines as the LC50 level exceeds the maximally attainable vapor
concentrations under the test conditions. - Executive summary:
Five male and five female rats were exposed to 6193 mg/m3 (>6.193 mg/l) air vapors of test material MRD-95-374 for 4 hrs. Animals were observed for 14 days. Animals continued to gain weight through day 14. There was no mortality and no gross pathological alterations noted in any of the animals. Based on an LC50 >6193 mg/m3 (>6.193 mg/L) air and other data, test substance Hydrocarbons,C9 aromatics is not classified under either the EU GHS guidelines or under the EU dangerous substances preparations guidelines as the LC50 level exceeds the maximally attainable vapor concentrations under the test conditions.
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Done in accordance to basic scientific principles.
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River
- Age at study initiation: 7-8 weels
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum - Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- Two rats of each sex age 7and 8 weeks were housed in a tubular glass chamber, and exposed for 4 hours to test atmospheres by the near saturation of air supplied to the test chamber. The animals were observed over the subsequent 14 days. Food and water were available to the animals at all times except for the 4 hour exposure period.
The concentration of solvent in the test atmosphere was monitored continuously during the exposure by means of a high temperature total hydrogen analyzer. The instrument was calibrated using a gravimetric procedure. - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- high temperature total hydrogen analyzer
- Duration of exposure:
- 4 h
- Concentrations:
- 10.2 mg/L (approx 2000 ppm)
- No. of animals per sex per dose:
- two rats of each sex
- Control animals:
- no
- Details on study design:
- Two rats of each sex age 7and 8 weeks were housed in a tubular glass chamber, and exposed for 4 hours to test atmospheres by the near saturation of air supplied to the test chamber. The animals were observed over the subsequent 14 days. Food and water were available to the animals at all times except for the 4 hour exposure period.
The concentration of solvent in the test atmosphere was monitored continuously during the exposure by means of a high temperature total hydrogen analyzer. The instrument was calibrated using a gravimetric procedure. - Statistics:
- none
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 10.2 mg/L air (nominal)
- Remarks on result:
- other: (approx 2000 ppm)
- Mortality:
- No mortality was noted.
- Clinical signs:
- other:
- Interpretation of results:
- other: Not classified
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The LC50 was >10.2 mg/l (approx 2000 ppm). The LC50 for acute inhalation exposure to the test material vapor is greater than the highest obtainable vapor concentration. Classification as an acute inhalation toxicant is not warranted under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) or under Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations.
- Executive summary:
The acute inhalation toxicity of the test material was evaluated in four CD rats. Animals were exposed for four hours to the maximum attainable vapor concentration of the test material >10.2 mg/l (approx 2000 ppm) in individual inhalation chambers. Animals were observed for 14 days. There were no mortality or gross pathological alterations noted in any of the animals. Based on the conditions of this study, the LC50 for vapors of Hydrocarbons, C9 Aromatics are greater than >10.2 mg/l (approx 2000 ppm). Classification as an acute inhalation toxicant is not warranted under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) or under Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations.
Referenceopen allclose all
Summary of other acute inhalation toxicity studies.
End Point | Study Reference | ||||||||||||||||||||||||
REACH requirement | IUCLID Section | Study Name | Data Waiving | Waiving Justification | Species | Study Result Type | Test Guideline/Qualifier | Test Guideline/Guideline | Test Guideline/Deviations | Reliability | Rational For Reliability | GLP Compliance | Test Materials/Identity | Study Result | Reference Type | Reference Author | Reference Year | Reference Title | Bibliographic Source | Testing Laboratory | Reference Report No. | Owner Company | Company Study No. | Report Date | Data access |
8.5.2 Acute toxicity inhalation | 7.2.2 | Inhalation | rat | Experimental result | No guideline followed. | 2 | Summary only of study. | No data | Shellsol A | LC50 > 10.2 mg/L | Study report | Coombs, AD, Blair, D, Doak, SM, Carter, BI | 1977 | The Acute Toxicity of Shellsol A | HSPA0690 | Sittingbourne Research Centre | M(T)-1-77 | Shell Chemicals Europe BV | June, 1977 | yes | |||||
8.5.2 Acute toxicity inhalation | 7.2.2 | Acute Vapor Inhalation Toxicity Study - Albino Rats, Mice and Guinea Pig | rat, mice, guinea pig | Experimental result | Equivalent or similar to | OECD guideline 403 | 5 animals used per species (not 10); dry air stream used to generate vapors so no particulate analysis was done. | 2 | The study is scientifically sound, however, it was not performed in strict accordance with OECD guidelines. | No | MRD-ECH-74-22 | LC50 > 14.4 mg/L | Study report | ANON | 1975 | Acute Vapor Inhalation Toxicity Study - Albino Rats, Mice and Guinea Pig | HSPA0153 | Industrial BioTest Laboratories, Inc. | 663-06262 | ExxonMobil Petroleum & Chemical BVBA | 75MRL17 | 27/03/1975 | yes | ||
8.5.2 Acute toxicity inhalation | 7.2.2 | The Acute 4 H Inhalation LC50 of Hydrogenated Shellsol A in Rats | rat | Experimental result | No guideline followed. | 1 | Well-documented study. | No | Hydrogenated Shellsol A | LC50 =14.0 mg/L | Study report | Blair, D | 1982 | The Acute 4 H Inhalation LC50 of Hydrogenated Shellsol A in Rats | HSPA0691 | Sittingbourne Research Centre | Shell Chemicals Europe BV | SBGR.82.037 | Jan. 1982 | yes | |||||
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 6 193 mg/m³ air
- Quality of whole database:
- Two key read across studies available for assessment.
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1984/03/01-1984/03/15
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Similar to OECD Guideline 402: Acute Dermal Toxicity
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- Used 3 male and 3 female rabbits instead of recommended 5 for each sex; occlusive patch used
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hazelton Dutchland, Inc.
- Sex: male (3), female (3)
- Age at study initiation: appox. 19 weeks
- Weight at study initiation: 2,99-3.61 kg
- Housing: Individually
- Diet (e.g. ad libitum): Purina certified rabbit chow HF, ad libitum
- Water (e.g. ad libitum): Automatic watering system, ad libitum
- Acclimation period: 52 days
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 65-71
- Humidity (%): 40-70
- Photoperiod (hrs dark / hrs light): 12/12 - Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Dorsal surface
- Type of wrap if used: gauze patch covered with a plastic sleeve
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Distilled water and paper towels
- Time after start of exposure: 24 hrs
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 3160 mg/kg
- Concentration (if solution): Assumed to be 100%; density of 0.8578 g/ml
- Constant volume or concentration used: yes - Duration of exposure:
- 24 hrs
- Doses:
- one dose: 3160 mg/kg
volume: 11-13 ml - No. of animals per sex per dose:
- 3 males, 3 females
- Control animals:
- no
- Details on study design:
- SCORING SYSTEM: Draize scale
- Duration of observation period following administration: 2, 4, 24 hrs after dosing and once per day thereafter for 14 days
- Dermal response observations: 24 hrs, 3, 7, 10, and 14 days
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs, body weight - Statistics:
- The mean and standard deviations for the body weights and body weight changes were calculated.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3 160 mg/kg bw
- Mortality:
- There were no animal deaths prior to study termination.
- Clinical signs:
- other: Overall low incidence of clinical in-life observations. -Most frequently noticed: desquamation, atonia, leathery skin, and eschar. At the termination of the study all animals exhibited desquamation. -Low Incidences: soft stool and small amount of stool,
- Gross pathology:
- All animals displayed very slight to well-defined erythema from day 0 to day 7. By day 14, only two animals still showed erythema; one having a very slight grade noted. Many animals exhibited very slight edema in a similar time frame.
Desquamation (6 animals), atonia (2 animals), leathery skin (2 animals), and eschar (1 animal) were noted through out the observational time period. At the termination of the study all animals exhibited desquamation.
Two animals were noted as being hyperactive and having a red nasal discharge after dosing. There was a single incidence of slight vocalization following dosing. - Other findings:
- GROSS POSTMORTEM EXAMINATION
Alopecia for 1 animal (abdominal).
Severe erythema for 1 animal at the dosing site.
Desquamation for all animals at the dosing site. - Interpretation of results:
- other: Not classified
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 > 3160 mg/kg based on these data, MRD-83-208 is not classified under EU requirements for dangerous substances and preparations. MRD-83-208 is also not classified under GHS guidelines.
- Executive summary:
Three male and female rabbits were exposed to MRD-83 -208 for 24 hrs via an occluded patch. Dermal evaluations occurred at 24 hrs post patch removal and on days 3, 7, 10, 14. Exposure had no affect on viability; all animals survived the exposure. It is concluded that the LD50 in this situation is greater than 3160 mg/kg. MRD-83 -208 is not classified under EU dangerous substances and preparations guidelines. MRD-83 -208 is also not classified under GHS guidelines.
Reference
Summary of other acute dermal toxicity studies.
End Point | Study Reference | ||||||||||||||||||||||||
REACH requirement | IUCLID Section | Study Name | Data Waiving | Waiving Justification | Species | Study Result Type | Test Guideline/Qualifier | Test Guideline/Guideline | Test Guideline/Deviations | Reliability | Rational For Reliability | GLP Compliance | Test Materials/Identity | Study Result | Reference Type | Reference Author | Reference Year | Reference Title | Bibliographic Source | Testing Laboratory | Reference Report No. | Owner Company | Company Study No. | Report Date | Data access |
8.5.3 Acute toxicity, dermal route | 7.2.3 | Acute percutaneous toxicity | rat | Experimental result | According to | Noakes, D.N., and Sanderson, D.M. (1969). A method for determining the dermal toxicity of pesticides. Br. J. Industr. Med.,26, 59-64. | 2 | Summary only of study. | No data | Shellsol A | LD50 > 4 ml/kg | Study report | Coombs, AD, Blair, D, Doak, SM, Carter, BI | 1977 | The Acute Toxicity of Shellsol A | HSPA0692 | Sittingbourne Research Centre | M(T)-1-77 | Shell Chemicals Europe BV | June, 1977 | yes |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 160 mg/kg bw
- Quality of whole database:
- One key read across study available for assessment.
Additional information
There is no data available for Hydrocarbons, C10, aromatics, <1% naphthalene. However, data is available for structural analogues, Hydrocarbons, C9 aromatics and Hydrocarbons, C10 aromatics and presented in the dossier. This data is read across to based on analogue read across and a discussion and report on the read across strategy is provided as an attachment in IUCLID Section 13.
Acute Oral Toxicity
Hydrocarbons, C9, aromatics
A key study (Shell, 1977a) was conducted to determine the acute oral toxicity of Hydrocarbons, C9, aromatics in rats. 2 male and 2 female rats were dosed with 1, 2, 4, or 8 mL/Kg of test substance via oral gavage. One female rat in the 4 mL/Kg exposure group died, and both females in the 8 mL/Kg exposure group died after showing signs of lethargy and ataxia. None of the male rats in the study died. The LD50 for female rats is then 4 mL/Kg. The LD50 for male rats is > 8 mL/Kg (6984 mg/Kg bw). According to EU GHS guidelines, the test substance is not classified as being toxic.
Acute Inhalation Toxicity
Hydrocarbons, C9, aromatics
In a key acute inhalation toxicity study (ExxonMobil, 1996), five male and five female rats were exposed to 6193 mg/m3(>6.193 mg/L) air vapors of the test material (Hydrocarbons, C9, aromatics) for 4 hrs. Animals were observed for 14 days. Animals continued to gain weight through day 14. There was no mortality and no gross pathological alterations noted in any of the animals. Based on an LC50>6193 mg/m3(>6.193 mg/L) air and other data, the test substance Hydrocarbons,C9 aromatics is not classified under either the EU GHS guidelines as the LC50 level exceeds the maximally attainable vapor concentrations under the test conditions.
In another key study (Shell, 1976), the acute inhalation toxicity of the test material (Hydrocarbons, C9, aromatics) was evaluated in four CD rats. Animals were exposed for four hours to the maximum attainable vapor concentration of the test material >10.2 mg/L (approx 2000 ppm) in individual inhalation chambers. Animals were observed for 14 days. There were no mortality or gross pathological alterations noted in any of the animals. Based on the conditions of this study, the LC50for vapors of Hydrocarbons, C9 Aromatics are greater than >10.2 mg/L (approx 2000 ppm). Classification as an acute inhalation toxicant is not warranted under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP).
Hydrocarbons, C10, aromatics
In a supporting acute inhalation toxicity study (Carpenter et al. 1977), the LC50s reported for Hydrocarbons, C10, aromatics were >6.3 mg/L in rats; >8.2 mg/L in cats; and >1 mg/L in dogs. Classification as an acute inhalation toxicant is not warranted under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP).
Acute Dermal Toxicity
Hydrocarbons, C9, aromatics
In a key acute dermal toxicity study (ExxonMobil, 1984), three male and female rabbits were exposed to the test material (Hydrocarbons, C9, aromatics) for 24 hrs via an occluded patch. Dermal evaluations occurred at 24 hrs post patch removal and on days 3, 7, 10, 14. Exposure had no affect on viability; all animals survived the exposure. It is concluded that the LD50 in this situation is greater than 3160 mg/Kg. Hydrocarbons, C9, aromatics is not classified under EU dangerous substances and preparations guidelines. Hydrocarbons, C9, aromatics is also not classified under GHS guidelines.
Justification for classification or non-classification
Based on the available read across data, Hydrocarbons, C10, aromatics, <1% naphthalene does not warrant classification as an acute oral, dermal, or inhalation toxicant under the new Regulation (EC) 1272/2008 on classification, labelling and packaging of substances and mixtures (CLP). On the basis of available physical and chemical property data (hydrocarbon fluid, viscosity ≤ 20.5 mm2/s), Hydrocarbons, C10, aromatics, <1% naphthalene is classified under EU CLP guidelines as a Category 1 aspiration hazard (H304).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.