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Diss Factsheets
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EC number: 424-560-4 | CAS number: 151257-01-1 SR 48001 A
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study was conducted according to OECD and in accordance with GLP. The study material is well characterized.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: PFA-SD (IOPS Caw)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: IFFA- Credo
- Age at study initiation: 5 weeks
- Weight at study initiation: 136 to 161 g- male; 119-131 g-emales
- Fasting period before study: 18 hours
- Housing: 2 to 3 per same group in stainless steel cage
- Diet (e.g. ad libitum): UAR AO4C
- Water (e.g. ad libitum): tap water
- Acclimation period: 5 days before
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22+-2 C
- Humidity (%): 40-70 %
- Air changes (per hr): 10 to 11
- Photoperiod (hrs dark / hrs light):12/24
IN-LIFE DATES: From: Feb 17th, 1994 To:March 4, 1994
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 0.6 % methyl cellulose aqueous solution
- Details on oral exposure:
- Using all available information on the toxicity of the test material, 2000 mg/kg was chosen as the starting dose.
dose level: 0, 1000, 2000 mg/kg male; 0, 2000 female
concentration: 10 ml/kg - Doses:
- dose level: 0, 1000, 2000 mg/kg male; 0, 2000 female
- No. of animals per sex per dose:
- 5 females/males per dose.
- Control animals:
- yes
- Details on study design:
- The animals were observed for deaths or overt signs of toxicity for fifteen days. All animals were subjected to macroscopic pathological observations. Body weights were recorded on days D1,D3,D8 and D15.
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- >= 1 000 - <= 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There were 2 deaths. time of death after dosing
one animal: mortality occurred within 24 hours following treatment - Clinical signs:
- other: Signs of systemic toxicity noted: >=1000 mg/kg- pytalism, decubitus on D1 ( males only 5/5) >= 2000 mg/kg - prostration, piloerection on D1( 5M/5, 5F/5) piloerection and urogenital area on D2 ( 2M/2, 5F/5)
- Gross pathology:
- at 2000: l
ungs - dark red (3/3); non-collapsed (2/3)
stomach - hemorrhagic contents (2/3)
spleen: pales (1/3)
soiled urogenital area ( 2/3)
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral median lethal dose (LD50) of the test material was greater than 2000 mg/kg bodyweight for females and approximately 2000 mg/kg males.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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