Registration Dossier
Registration Dossier
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EC number: 201-195-7 | CAS number: 79-31-2
Endpoint summary
Administrative data
Description of key information
Additional information
No data could be identified for the terrestrial toxicity of isobutyric acid.
Waiving argument:
In accordance with column 2 of REACH Annexes IX and X, terrestrial studies do not need to be conducted if direct and indirect exposure of the soil compartment is unlikely.
Direct exposure to soil is not likely, since the substance is not intentionally applied to soil. Indirect exposure to soil is also not likely since the substance is readily biodegradable and has a low adsorption potential (log Koc < 3).
In conclusion no testing is required.
The equilibrium partitioning method will be applied to assess the hazard to soil organisms. In accordance with
column 2 of REACH Annex X, any need for testing should be carefully considered taking into account the large
mammalian dataset that is usually available at this tonnage level.
Exposure of birds is generally only considered for the fish and earthworm food chains following the release of a
substance via a sewage treatment works. It is unlikely that a secondary poisoning risk will be identified for isobutyric
acid since it is readily biodegradable and has a low log Kow below 3.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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