Registration Dossier
Registration Dossier
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EC number: 213-030-6 | CAS number: 917-61-3
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1946
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- not given
- Author:
- Anonymus
- Year:
- 1 946
- Bibliographic source:
- British Journal of Pharmacology and Chemotherapy. Vol. 1, Pg. 186, 1946
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Public available literature. No guideline indicated. For details on method see materials and methods section.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium cyanate
- EC Number:
- 213-030-6
- EC Name:
- Sodium cyanate
- Cas Number:
- 917-61-3
- Molecular formula:
- CNO.Na
- IUPAC Name:
- sodium cyanate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- not indicated.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not indicated.
Administration / exposure
- Route of administration:
- intramuscular
- Vehicle:
- not specified
- Details on exposure:
- not indicated.
- Doses:
- not indicated.
- No. of animals per sex per dose:
- not indicated.
- Control animals:
- not specified
- Details on study design:
- not indicated.
- Statistics:
- not indicated.
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 310 mg/kg bw
- Mortality:
- not indicated.
- Clinical signs:
- Behavioral - altered sleep time (including change in righting reflex)
Behavioral - convulsions or effect on seizure threshold
Kidney/Ureter/Bladder - urine volume increased - Body weight:
- not indicated.
- Gross pathology:
- not indicated.
- Other findings:
- not indicated.
Applicant's summary and conclusion
- Conclusions:
- LD50 (mice, intramuscular administration) = 310 mg/kg bw.
- Executive summary:
In an acute toxicity study (intramuscular administration), groups of mice were given doses of sodium cyanate.
LD50 = 310 mg/kg bw
Clinical signs:
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - convulsions or effect on seizure threshold
Kidney/Ureter/Bladder - urine volume increased
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