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EC number: 200-712-3 | CAS number: 69-72-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- data not available
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The method and the test conditions are sufficiently described to assess the results. The quantity of salicylic acid applied is unknown.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Relationship of pKa and acute skin irritation in humans.
- Author:
- Berner B, Wilson DR, Mazzenga GC et al
- Year:
- 1 989
- Bibliographic source:
- J. Toxicol. - Cut. & Ocular Toxicol., 9(2), 481-492.
Materials and methods
- Study type:
- study with volunteers
- Endpoint addressed:
- skin irritation / corrosion
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Test substance was applied on day 1 on the back of woman. On day 2 the patches were removed and erythema and edema were scored by standard 0-4 visual scales. On day 3 the procedure of day 2 was repeated.
- GLP compliance:
- no
Test material
- Reference substance name:
- Salicylic acid
- EC Number:
- 200-712-3
- EC Name:
- Salicylic acid
- Cas Number:
- 69-72-7
- Molecular formula:
- C7H6O3
- IUPAC Name:
- 2-hydroxybenzoic acid
- Details on test material:
- - Name of test material (as cited in study report): salicylic acid (Fisher, Springfield, NJ)
no other data
Constituent 1
Method
- Type of population:
- general
- Subjects:
- - Number of subjects exposed: 16
- Sex: female
- Age: 35 to 45
- Race: 10 were hispanic origin with various degrees of olive-complected skin. 5 were white with type II skin, and one was a white/Polynesian mixture with a slightly olive skin tone.
- other: All subjects had reasonably clear backs with no or few comedones, moles, or freeckles. - Ethical approval:
- not specified
- Route of exposure:
- dermal
- Reason of exposure:
- intentional
- Exposure assessment:
- estimated
- Details on exposure:
- Sixteen female subjects (with reasonable clear backs) ranging from 35 to 45 years of age consented to the study.
The scapular regions of the upper back unoccluded by undergarments were tested. Baseline scoring and measurements were taken. The relative humidity and temperature were noted. The loaded test discs were applied to the skin occluded with 3% ethylene vinyl acetate membrane and secured with tape. On day 2, the patches were removed and the measurement was repeated. Erythema and edema were scored by standard 0-4 visual scale by Draize, with an additional scale at 0.5 to signify borderline reaction. Blow flow and color were measured too.
On day 3, procedure of day 2 was repeated. Primary irritation index was calculated as the average for the 2 time points of the sum of the erythema and edema scores. - Examinations:
- - Other: skin irritation was evaluated.
- Medical treatment:
- None
Results and discussion
- Clinical signs:
- No data
- Results of examinations:
- Mean scores for salicylic acid were:
24hr erythema 1.0 +/- 0.9; edema 0.8 +/- 0.9
48hr erythema 0.7 +/- 0.8; edema 0.6 +/- 0.8
Control = water
24hr erythema 0.03 +/- 0.18; edema 0.03 +/- 0.18
48hr erythema 0.06 +/- 0.21; edema 0.00 - Effectivity of medical treatment:
- not applicable
- Outcome of incidence:
- not applicable
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of this test, salicylic acid is slightly irritant.
- Executive summary:
In a pKa and human skin irritation (Berner et al., 1989/90), a skin irritation study with human volunteers was performed. Sixteen woman ranging from 35 to 45 years of age consented to the study. Ten were of Hispanic origin with various degrees of olive-complected skin. Five were white type II skin, and one was a white/Polynesian mixture with a slightly olive skin tone. All subjects had reasonably clear backs with no or few comedones, moles, or freckles. On day 1 the subjects acclimated for a half hour during which time the sites was marked on the back with a felt tip marker. The scapular regions of the upper back unoccluded by undergarnents were tested. Two replicates per subject and a distilled water control were performed. Baseline scoring and measurements were taken. The relative humidity and temperature were noted. The loaded test discs were applied to the skin occluded with 3 % ethylene vinyl acetate membrane and secured with tape. On day 2 the patches were removed and the sites marked again. Thirty minutes later, the measurements were repeated. Erythema and edema were scored by standard 0 -4 visual scales, with an additional scale at 0.5 to signify borderline reaction. Blood flow assessed by laser Doppler velocimetry and color were measured. On day 3 the procedure of day 2 was repeated. Erythema and Edema scores at 24h were 1.0 +/-0.9 and 0.8 +/- 0.9 respectively. Erythema and Edema scores at 48h were 0.7 +/- 0.8 and 0.6 +/- 0.8 respectively. Under the conditions of this test, salicylic acid showed a slight irritant effect.
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