Registration Dossier
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EC number: 293-054-1 | CAS number: 91051-05-7
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No acute toxicity up to the limit of water solubility.
Key value for chemical safety assessment
Additional information
There are no studies on fish toxicity available for Fatty acids essential, Et esters (CAS 91051 -05 -7). The assessment of fish toxicity was therefore based on studies conducted with the structurally most similar category members, for which data is available, Ethyl linoleate (CAS 544-35-4) and Fatty acids, C8-16, 2-ethylhexyl esters (CAS 135800-37-2), as part of a read across approach, which is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach. Further justification is given within the endpoint summary 6.1 and within the category justification section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was entered into IUCLID. Nevertheless, as can be seen in the data matrix of the category justification in Section 13, all reliable data in the category support the hazard assessment for this endpoint, by showing a consistent pattern of results.
In the selected study, the acute toxicity of Ethyl linoleate to Cyprinus carpio was tested under static conditions according to OECD 203 and GLP (Bouwman 2010). The time weighted average of the bioavailable concentration (after filtration with a glass fibre filter) resulted in a value of 0.2 mg/L. Since no toxic or sublethal effects were observed within the incubation period of 96 hours at the limit of water solubility, an EC50(96h) > 0.2 mg/L was stated.
In a read-across from Fatty acids, C8-16, 2-ethylhexyl esters (CAS 135800-37-2), the marine species Scopthalmus maximus was tested with a WAF, resulting in a nominal LL50(96h) value > 5600 mg/L (Hudson 2002).
Thus, based on the above mentioned result, and due to the structural and profile similarities of the substances, as are explained with in the overall endpoint summary 6.1 it can be concluded that no toxicological effects on fish are expected up to the limit of water solubility for Fatty acids, essential, Et esters (CAS 91051-05-7).
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