Registration Dossier
Registration Dossier
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EC number: 231-211-8 | CAS number: 7447-40-7
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- publication
- Title:
- Distribution in body fluids and excretion of ingestes ammonium chloride, potassium chloride and sodiun chloride
- Author:
- Bourdillon J
- Year:
- 1 937
- Bibliographic source:
- Am J Physiol 120. 411-419
Materials and methods
- Objective of study:
- other: distribution and excretion
- Principles of method if other than guideline:
- single oral application to male volunteers and the changes in serum electrolytes, interstitial fluid volume and electrolyte excretion were obbserved for several hours.
- GLP compliance:
- no
Test material
- Reference substance name:
- Potassium chloride
- EC Number:
- 231-211-8
- EC Name:
- Potassium chloride
- Cas Number:
- 7447-40-7
- Molecular formula:
- KCl
- IUPAC Name:
- potassium chloride
- Details on test material:
- no further details
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- human
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- water
- Duration and frequency of treatment / exposure:
- single application
Doses / concentrations
- Remarks:
- Doses / Concentrations:
no data
- No. of animals per sex per dose / concentration:
- number of volunteers in test is not mentioned
- Control animals:
- no
Results and discussion
Main ADME results
- Type:
- other: distribution and excretion
- Results:
- Cl anion diffuses into the interstitial fluid only, and does not enter the tissue cells; K kation diffuses in to the total body fluids; Serum HCO3 anion was reduced: one third excretion in urine and two third as KHCO3 into tissue cells
Metabolite characterisation studies
- Metabolites identified:
- no
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
