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EC number: 236-671-3 | CAS number: 13463-41-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- two-generation reproductive toxicity
- Remarks:
- based on test type (migrated information)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.3800 (Reproduction and Fertility Effects)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Pyridine-2-thiol 1-oxide, sodium salt
- EC Number:
- 223-296-5
- EC Name:
- Pyridine-2-thiol 1-oxide, sodium salt
- Cas Number:
- 3811-73-2
- Details on test material:
- - Analytical purity: 40.8%
- Lot/batch No.: 99072150
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Nossan Srl
- Age at study initiation: 5-6 weeks
- Weight at study initiation: male 19.3g female 15.1g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on mating procedure:
- Pairing for 2 weeks then change of animals within the treatment group.
- Duration of treatment / exposure:
- -Parents 10 weeks before mating and thereafter through the day prior to sacrifice
-F1 from the day after selection (nominal day 22)
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 0.7, 1.4, 2.8 mg/kg bw
Basis:
- No. of animals per sex per dose:
- 24
Examinations
- Parental animals: Observations and examinations:
- -CLinical signs
-Body weight
-Food consumption - Oestrous cyclicity (parental animals):
- -Parent and F1 from 2 weeks prior to paring until mating
- Sperm parameters (parental animals):
- -Sperm viability and motility
-Testicular resistant sperm heads
-Testis weight
-Epididymus weight - Litter observations:
- -Number and sex of pups
-Still births
-Live births
-Presence of gross anomalies
-Weight gain
-Vaginal opening
-Balano preputial separation
-Testes descent - Postmortem examinations (parental animals):
- -Organ weights: adrenal glands, brain, testes, kidneys, liver, ovaries, pituitary, spleen, uterus, epididymides (total and cauda), seminal vesicles, prostate
-Histopathology: vagina, uterus, ovaries, testis, epididymis, seminal vesicle, prostate, coagulating gland, pituitary, adrenals, abnormalities - Postmortem examinations (offspring):
- - F1 Organ weights: adrenal glands, brain, testes, kidneys, liver, ovaries, pituitary, spleen, uterus, epididymides (total and cauda), seminal vesicles, prostate
- F1 Histopathology: vagina, uterus, ovaries, testis, epididymis, seminal vesicle, prostate, coagulating gland, pituitary, adrenals, abnormalities
Results and discussion
Results: P0 (first parental generation)
Details on results (P0)
-Parent female: Emaciation in high dose females. Lower body weight in high dose females, compared to the control. Lower food consumption in high dose females, compared to the control. Lower terminal body weight in high dose animals. Lower kidney weights in mid and high dose females. Higher uterus weight in mid and high dose females. No relevant macroscopic or microscopic post-mortem findings.
-F1 male: Slightly later prepuzial serparation in high dose animals. Lower body weight in high dose males, compared to the control. Lower terminal body weight in high dose animals. No differences in sperm analysis.
-F1 female: Emaciation in high dose females. Lower body weight in high dose females, compared to the control. Lower food consumption in high dose females, compared to the control. Lower terminal body weight in high dose animals. Higher spleen weight in females and lower epididymes weight in males of the high dose group. No relevant macroscopic or microscopic post-mortem findings
-F2: Lower mean pup weight and litter weight in mid or/and high dose groups before/at weaning. Increase in pup loss in mid dose animals on Day 4 post partum. Pups with testis not descended in mid and high dose groups.
Effect levels (P0)
open allclose all
- Dose descriptor:
- LOAEL
- Effect level:
- 2.8 mg/kg bw/day (nominal)
- Sex:
- male
- Dose descriptor:
- LOAEL
- Effect level:
- 1.4 mg/kg bw/day (nominal)
- Sex:
- female
- Dose descriptor:
- NOAEL
- Effect level:
- 1.4 mg/kg bw/day (nominal)
- Sex:
- male
- Dose descriptor:
- NOAEL
- Effect level:
- 0.7 mg/kg bw/day (nominal)
- Sex:
- female
Results: F1 generation
Effect levels (F1)
open allclose all
- Dose descriptor:
- LOAEL
- Generation:
- F1
- Effect level:
- 2.8 mg/kg bw/day (nominal)
- Sex:
- male
- Dose descriptor:
- LOAEL
- Generation:
- F1
- Effect level:
- 1.4 mg/kg bw/day (nominal)
- Sex:
- female
- Dose descriptor:
- NOAEL
- Generation:
- F1
- Effect level:
- 1.4 mg/kg bw/day (nominal)
- Sex:
- male
- Dose descriptor:
- NOAEL
- Generation:
- F1
- Effect level:
- 0.7 mg/kg bw/day (nominal)
- Sex:
- female
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Various toxic signs, such as lower body weight, lower food consumption, emaciation in females, lower pup weight, later descending of testis, later prepuzial separation were observed in the high dose group (2.8 mg as /kg bw) and in a few cases also in the mid dose group (1.4 mg as /kg bw). This information may not be used for any purpose other than in support of the Chemical safety Report submitted by Arch Chemicals Inc. under Regulation EC 1907/2006.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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