Registration Dossier
Registration Dossier
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EC number: 701-025-6 | CAS number: 26038-87-9
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: Expert review and assessment
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Not assignable as the result is from expert assessment.
- Objective of study:
- other: Basic toxicokinetic assessment to support REACH registration
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Expert review of available data.
- GLP compliance:
- no
- Conclusions:
- No toxicokinetic (absorption, metabolism, distribution, elimination) data is available for MEA-Polyborate. Available data is primarily physico-chemical properties that influence the absorption and distribution of the substance in the body. Both 1:1 and 1:3 mole ratios of MEA to boric acid are infinitely soluble in water with log Pow of -0.9 for the polyborate moiety by ICP-MS and log Pow of -2.5 for the organic moiety by LC-MS. The log P values indicate that both ratios of MEA-Polyborate will likely be 100% absorbed in the gastrointestinal track, primarily found in the blood serum and excreted primarily via the kidneys in the urine. The log P values also indicate that both ratios of MEA-Polyborate is poorly absorbed through the skin with dermal absorption rates similar to monoethanolamine. No data is available on the metabolism of MEA-Polyborate.
Reference
No toxicokinetic (absorption, metabolism, distribution, elimination) data is available for MEA-Polyborate. Available data is primarily physico-chemical properties that influence the absorption and distribution of the substance in the body. Both 1:1 and 1:3 mole ratios of MEA to boric acid are infinitely soluble in water with log Pow of -0.9 for the polyborate moiety by ICP-MS and log Pow of -2.5 for the organic moiety by LC-MS. The log P values indicate that both ratios of MEA-Polyborate will likely be 100% absorbed in the gastrointestinal track, primarily found in the blood serum and excreted primarily via the kidneys in the urine. The log P values also indicate that both ratios of MEA-Polyborate is poorly absorbed through the skin with dermal absorption rates similar to monoethanolamine. No data is available on the metabolism of MEA-Polyborate.
Description of key information
No toxicokinetic (absorption, metabolism, distribution, elimination) data is available for MEA-Polyborate. Available data is primarily physico-chemical properties that influence the absorption and distribution of the substance in the body. Both 1:1 and 1:3 mole ratios of MEA to boric acid are infinitely soluble in water with log Pow of -0.9 for the polyborate moiety by ICP-MS and log Pow of -2.5 for the organic moiety by LC-MS. The log P values indicate that both ratios of MEA-Polyborate will likely be 100% absorbed in the gastrointestinal track, primarily found in the blood serum and excreted primarily via the kidneys in the urine. The log P values also indicate that both ratios of MEA-Polyborate is poorly absorbed through the skin with dermal absorption rates similar to monoethanolamine. No data is available on the metabolism of MEA-Polyborate.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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