Isobutyraldehyde

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Range-finding toxicity data

Author:

Smyth H.F.

Year:

1954

Bibliographic source:

AMA Arch Ind Hyg Occup Med. 1954 Jul;10(1):61-8.

Reference 2

Reference Type:

publication

Title:

Unnamed

Year:

1991

Report date:

1991

Reference 3

Reference Type:

publication

Title:

Industrial hygiene and toxicology, Second Revised Edition, Volume II

Author:

Fassett D.W.

Year:

1962

Bibliographic source:

p. 1966-1978

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Principles of method if other than guideline:

Five female Carworth Wistar per dose were exposed to the test substance. Based upon mortalities during a 14-day observation period, the most probable LD50 value and its fiducial range are estimated by the method of Thompson using the tables of Weil.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Isobutyraldehyde

EC Number:

201-149-6

EC Name:

Isobutyraldehyde

Cas Number:

78-84-2

Molecular formula:

C4H8O

IUPAC Name:

2-methylpropanal

Details on test material:

- Name of test material: isobutyraldehyde

Test animals

Species:

rat

Strain:

other: Carworth Wistar

Sex:

female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Mellon Institute of Industrial Research, University of Pittsburg
- Age at study initiation: 5-6 weeks
- Weight at study initiation: 90 – 120 g
- Fasting period before study: not performed
- Diet: Rockland rat diet

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

other: 1% solution of sodium 3,9-diethyl-6-tridecanol sulfate (Tergitol Penetrant 7)

Details on oral exposure:

Administered as a 20% aqueous dispersion in 1% Tergitol Penetrant 7

Doses:

2000, 3980, 7950 mg/kg

No. of animals per sex per dose:

5

Control animals:

not specified

Details on study design:

Duration of observation period following administration: 14 days

Statistics:

LD50 and its fiducial range are estimated by the method of Thompson using the tables of Weil.

Results and discussion

Effect levels

Key result

Sex:

female

Dose descriptor:

LD50

Effect level:

3 730 mg/kg bw

Based on:

test mat.

95% CL:

2 680 - 5 210

Gross pathology:

Severe gastrointestinal tract necrosis was observed. The liver, spleen and kidneys were also necrosed where they contacted the stomach wall. Lungs wer markedly congested or hemorrhagic.