Registration Dossier
Registration Dossier
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EC number: 201-149-6 | CAS number: 78-84-2
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- secondary source
- Title:
- SIDS Initial Assessment report for SIAM 5: Isobutanal CAS No: 78-84-2
- Author:
- OECD SIDS
- Year:
- 2 004
Materials and methods
- Type of study / information:
- Effects after exposure of male volunteers
- Endpoint addressed:
- respiratory irritation
- Principles of method if other than guideline:
- 15 male volunteers exposed to 210 ppm vapour for 30 min
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Isobutyraldehyde
- EC Number:
- 201-149-6
- EC Name:
- Isobutyraldehyde
- Cas Number:
- 78-84-2
- Molecular formula:
- C4H8O
- IUPAC Name:
- 2-methylpropanal
- Details on test material:
- - Name of test material: Isobutanal
Constituent 1
Method
- Ethical approval:
- not specified
- Exposure assessment:
- not specified
- Details on exposure:
- 15 male volunteers were exposed to 210 ppm (620 mg/m3) isobutanal vapour for 30 min
Results and discussion
- Results:
- No irritation was observed. Nausea was noted by some of the subjects, and one subject vomited.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
