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Diss Factsheets
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EC number: 618-561-0 | CAS number: 9046-10-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1978-12-26 to 1979-01-17
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Remarks:
- Study conducted with methods similar to OECD Guideline 405. However, limited details were provided on the animals, environmental conditions and the test substance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- Limited details were provided on the animals, environmental conditions and the test substance.
- GLP compliance:
- no
Test material
- Test material form:
- liquid
- Details on test material:
- - Physical state: liquid
- Storage condition of test material: Room temperature
Constituent 1
- Specific details on test material used for the study:
- - Name as cited in study report: Poly[oxy(methyl-1,2-ethanediyl)], alpha-(2-aminomethylethyl)-omega-(2-aminomethylethoxy)
- Substance type: Active
- Color: clear
- Date of receipt: 1978-11-3
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Housing: The animals were housed two per cage in suspended wire mesh cages in a temperature controlled room reserved exclusively for rabbits on acute tests.
- Diet (e.g. ad libitum): ad libitum (fresh Purina Rabbit Chow)
- Water (e.g. ad libitum): ad libitum (tap water)
- Acclimation period: at least one week
- Other: The animals were in good health when received from the local supplier and remained in good health during the equilibration period in the laboratory. The cages and room were kept clean in accordance with the standards of AAALAC of which the laboratory was an approved member. Prior to testing, the rabbits' eyes were closely examined for signs of irritation or damage. Only rabbit with healthy eyes were used.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The untreated eye of each animal served as a control.
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 ml of the test substance was instilled into one eye of each rabbit. The lids were held together briefly to insure adequate distribution of the test substance over the surface of the eye. - Duration of treatment / exposure:
- No data were provided in the study on washing the eye after treatment. The eyes were scored up for up to 14 days.
- Observation period (in vivo):
- 14 days (The ocular reactions were graded at 1, 24, 48 and 72 hours and again at 7 days. If any corneal score was present on day 7, the eyes were scored again at 14 days.)
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): The study did not specify if washing was done.
SCORING SYSTEM: The eye irritation potential was determined as defined in 16 CFR 1500.3 and 1500.42. See below for scale used for scoring of ocular lesions (Draize, J.H. et al. J. Pharm. Exp. Ther. 82:377-390, 1944).
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- mean
- Time point:
- other: 1 h
- Score:
- ca. 41.3
- Max. score:
- 110
- Reversibility:
- not reversible
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- ca. 55.7
- Max. score:
- 110
- Reversibility:
- not reversible
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- mean
- Time point:
- other: 48 h
- Score:
- ca. 66.6
- Max. score:
- 110
- Reversibility:
- not reversible
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- ca. 61.4
- Max. score:
- 110
- Reversibility:
- not reversible
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- mean
- Time point:
- other: 7 d
- Score:
- ca. 57.3
- Max. score:
- 110
- Reversibility:
- not reversible
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- mean
- Time point:
- other: 14 days
- Score:
- ca. 72
- Max. score:
- 110
- Reversibility:
- not reversible
- Irritant / corrosive response data:
- The test substance was corrosive to the rabbit eye.
- Other effects:
- One animal died during the study.
Any other information on results incl. tables
Average Scores |
1 h |
24 h |
48 h |
72 h |
7 d |
14 d |
Cornea (max 80) |
18.3 |
30.0 |
40.8 |
34.2 |
35.0 |
54.0 |
Iris (max 10) |
5.0 |
6.7 |
7.5 |
9.2 |
5.0 |
0.0 |
Conjunctivae (max 20) |
18.0 |
19.0 |
18.3 |
18.0 |
17.3 |
18.0 |
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Conclusions:
- The test substance was evaluated for eye irritation in New Zealand White rabbits. Based on the results, the test substance was determined to be corrosive to the eyes and considered to be classified as category 1 (serious eye damage) according to CLP Regulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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