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EC number: 202-180-8 | CAS number: 92-70-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well performed GLP and OECD guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- of 1981
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3-hydroxy-2-naphthoic acid
- EC Number:
- 202-180-8
- EC Name:
- 3-hydroxy-2-naphthoic acid
- Cas Number:
- 92-70-6
- Molecular formula:
- C11H8O3
- IUPAC Name:
- 3-hydroxynaphthalene-2-carboxylic acid
- Details on test material:
- - Name of test material (as cited in study report): BONS TTR
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hoechst AG breeding colony
- Weight at study initiation: mean male 197 g, female 191 g
- Fasting period before study: 16h
- Housing: makrolon cages, groups of 5
- Diet (e.g. ad libitum): rat diet Altromin 1324, ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22+/- 2
- Humidity (%): 55 +/- 10
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 2% aqueous CMC (carboxymethyl cellulose)
- Details on oral exposure:
- The test substance was administered as a 25% preparation in the vehicle to each dose group. Hence, the administration volume/kg bw was 1.25 ml/kg bw in the lowest dose group and 5.0 ml/kg bw in the highest dose group.
- Doses:
- male: 800, 1000, 1250 mg/kg bw
female: 315, 500, 800, 1000, 1250 mg/kg bw - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days (or other?): 14 d
- Frequency of observations and weighing: weighing: 0, 7, 14 days post application, clinical signs: 10, 30, 60 min, 2, 4, 6 h, 1, 2, 3, 4-14 d post application
- Necropsy of survivors and animals found dead performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- Probit analysis.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 823 mg/kg bw
- 95% CL:
- >= 581 - <= 1 070
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 869 mg/kg bw
- 95% CL:
- >= 394 - <= 1 350
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 795 mg/kg bw
- 95% CL:
- >= 485 - <= 1 320
- Mortality:
- 315 mg/kg: 0/5 (f)
500 mg/kg: 2/5 (f)
800 mg/kg: 1/5 (m), 2/5 (f)
1000 mg/kg: 3/5 (m), 3/5 (f)
1250 mg/kg: 5/5 (m), 4/5 (f)
Mortality occurred within 35-200 minutes after dosing. - Clinical signs:
- other: Clinical signs were similar in both sexes. Principal clinical signs comprised reduced spontaneous activity, ventral and lateral recumbency and crawling in all dose groups, in addition to closure of eyes, hunched posture and accelarated breathing in severa
- Gross pathology:
- All animals which survived during the 14-day post-dosing observation period were free from macroscopic pathology findings. In decedent animals either light coloured spots or dark discoloration were evident in the liver at 500 and 800 mg/kg , whereas at 1000 and 1250 mg/kg dark discoloration of the liver was evident in all decedents. In addition, invagination, reddening and partial filling with transparent yellow liquid were evident in small intestines and hyperemia and/or yellowish white filling were evident in the gastrointestinal tract in a number of decedents at all doses.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- LD50 male/female: 823 mg/kg bw
LD50 male: 869 mg/kg bw
LD50 female: 795 mg/kg bw - Executive summary:
3-Hydroxy-2-naphthoic acid was tested for its acute toxicity in the rat according to OECD Guideline 401 and in compliance with GLP. An oral LD50 of 823 mg/kg bw was attained for both sexes, 869 mg/kg for males and 795 mg/kg for femles. Mortality occurred within 35-200 minutes after dosing. Principal clinical signs comprised reduced spontaneous activity, ventral and lateral recumbency and crawling in all dose groups, in addition to closure of eyes, hunched posture and accelarated breathing in several dose groups starting at approximately 10 to 30 min post administration. In addition, diarrhea was noted in several dose groups starting mainly at approximately 30 to 60 min post administration. As from the day after the administration all surviving animals were free from clinical signs. Bodyweight was unaffected by treatment with the test substance. No macroscopic pathology findings were evident in animals which survived the 14-day post-dosing observation period, whilst dark or mottled livers and signs of gastrointestinal irritation were evident in decedent animals. There was no indication of relevant sex-related differences in toxicity of the substance after single oral administration.
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