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Diss Factsheets
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EC number: 231-718-4 | CAS number: 7699-45-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- Not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for data waiving:
- other:
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- (No data about doses, controls, observation frequency, fasting period before study, age at study initiation, housing of animals)
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Zinc chloride
- EC Number:
- 231-592-0
- EC Name:
- Zinc chloride
- Cas Number:
- 7646-85-7
- IUPAC Name:
- zinc dichloride
- Details on test material:
- - Name of test material: Zinc chloride
- Other: Purchased from E Merck (Darmstadt, FRG)
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Panlab (Barcelona, Spain)
- Age at study initiation: No data
- Weight at study initiation: 24-28 g
- Fasting period before study: No data
- Housing: No data
- Diet: Standard pellet diet, ad libitum
- Water: Tap water, ad libitum
- Acclimation period: 7 d
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- VEHICLE
- Amount of vehicle (if gavage): 0.2 mL/30 g body weight
DOSAGE PREPARATION: Solutions were given at pH between 6.0 and 7.0. Sodium bicarbonate was used to adjust the pH when necessary.
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: A preliminary screening with small groups of 3 animals of each kind was carried out The LD50 values were then calculated according to the Litchfield and Wilcoxon method. - Doses:
- No data
- No. of animals per sex per dose:
- Preliminary screening: Three
Final study: Ten - Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 d
- Frequency of observations: No data
- Necropsy of survivors performed: No
- Other examinations performed: ConJunctivitis, piloerection, haemorrhages, haematomas in tail, asthenia, weight loss - Statistics:
- No data
Results and discussion
- Preliminary study:
- A preliminary screening with small groups of three animals of each kind was carried out. The LD50 values were then calculated according to the Litchfield and Wilcoxon method
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 260 mg/kg bw
- 95% CL:
- 775 - 2 300
- Remarks on result:
- other: Equivalent to 605 mg of Zn/kg
- Mortality:
- Mostly, deaths occurred during the first 48 h of test compound administration. No deaths occurred after three days.
- Clinical signs:
- Conjunctivitis, piloerection, asthenia, decreased food and water consumption and hemorrhages and hematomas in the tail
For details see Table 1 in "Remark on results including tables and figures" field. - Body weight:
- Slight weight loss
- Gross pathology:
- No data
- Other findings:
- No data
Any other information on results incl. tables
Table 1. Severity of physical and clinical signs in mice after zinc intoxication in a single dose
|
Number of days after zinc administration |
|||
1 |
2-3 |
4-7 |
8-14 |
|
Mortality rates on oral administration |
90% |
10% |
0% |
0% |
Conjunctivitis |
None |
+ |
+ |
None |
Piloerection |
None |
+ |
+ |
+ |
Hemorrhages and hematomas in the tail |
None |
+ |
+++ |
+++ |
Asthenia |
++ |
++ |
+ |
None |
Degreased food and water consumption, weight loss |
None |
+ |
+ |
None |
Mortality rates and physical and observational examination of rats are average for all zinc compounds.
+Light; ++Moderate; +++Severe
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- Under the test conditions, the acute oral LD50 was calculated to be 1,260 mg/kg (equivalent to 605 mg of Zn/kg).
- Executive summary:
A study was conducted to evaluate the acute oral toxicity of the test material in mice according to the OECD Guideline 401 (Acute Oral Toxicity).
Initially a preliminary screening study with small groups of three mice of each kind was carried out and the LD50 values were then calculated according to the Litchfield and Wilcoxon method. The main study was conducted with ten mice. Conjunctivitis, piloerection, asthenia, decreased food and water consumption and severe hemorrhages and hematomas in the tail vein were observed in mice.
Under the test conditions, the acute oral LD50 was calculated to be 1,260 mg/kg (equivalent to 605 mg of Zn/kg).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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