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Diss Factsheets
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EC number: 201-187-3 | CAS number: 79-22-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Methyl chloroformate was tested in the pre incubation assay according to OECD TG 471 with and without metabolic activation in S.typhimuriumTA98, TA100, TA1535 and TA1537 at dose levels of 5 -5000 µg /plate. No increase in the number of revertants was detected in any strain with and without metabolic activation. Vehicle controls and positive controls were valid. Cytotoxicity was observed (concentrations not stated). Methylchloroformate was not mutagenic in this assay (BASF AG, 1988).
Methylchloroformate was tested for chromosomal aberrations in a study comparable to OECD TG 473, with V79 cells at concentrations of 0.1, 1.0, 2.5 µl/mL. Positive and negative controls reacted appropriately. Cytotoxicity was observed (concentration not stated). Under the conditions described in this report, there was an unequivocal enhancement of the aberration rates 7 h and 28 h after the treatment of the cells with 2.5 µ1/ml in the presence of metabolic activation but the results were negative after 18 hours. No chromosomal aberrations were observed in the absence of metabolic activation. Methylchloroformate is considered ambigous for chromosomal aberrations in the presence of metabolic activation (LMP, 1986).
Short description of key information:
Methylchloroformate was not mutagenic in the Ames test. Ambiguous results were obtain in a chromosomal aberration as positive and negative results for chromosomal aberrations in the presence of metabolic activation. Ambiguous results are assumed to be due to cytotoxicity and/or deliberation of hydrochloric acid of methylchloroformate in the test system..
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
No classification concerning repeated dose toxicity is warranted according to EU Regulation 67/548 and EU Regulation 1272/2008 as classification criteria are not met.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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