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EC number: 203-978-9
CAS number: 112-50-5
A well reported study assessed the eye irritancy potential of 2 -(2
-ethoxyethoxy)ethanol along with a number of other test substances in
rabbits. Even without a washing stage, the substance showed minimal
iritis or corneal effects and minimal chemosis. Mild to moderate
onjunctival effects were seen but insufficient to warrant
classification. All significant effects appeared to reverse within 72
hours. The conclusion from this study is that the substance does not
warrant classification as an eye irritant.
Findings animal 1:
"-" The original readings for animal 2 for timepoints
48h and 72h are missing.
Mean values over 24, 48 and 72 hours:
Animal 1: Erythema: 0, Chemosis: 0, Opacity: 0,
Animal 2: data not available. Information for
24 hrs only: Erythema: 1, Chemosis: 0, Opacity: 0, Iritis: 0
In an eye irritation study which broadly followed the OECD guideline but
for which only comprehensive data was available for a single animals, 2
-(2 -(2 -methoxyethoxy)ethoxy)ethanol was instilled in the eyes of 2
rabbits, which were then observed for up to 8 days. No washout was used.
Minimal effects were observed. No chemosis, corneal opacity or iritis
was seen and only mild conjunctival odema which had certainly
disappeared within 8 days and possibly sooner. On the basis of this
information, this substance has a low potential for eye irritancy and
does not warrant classification as an eye irritant.
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