Registration Dossier
Registration Dossier
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EC number: 201-837-6 | CAS number: 88-51-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: publication not sufficient for full methodological assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
Test guideline
- Guideline:
- other: detailed description of methodology not published
- GLP compliance:
- not specified
- Limit test:
- yes
Test material
- Reference substance name:
- 4-amino-6-chlorotoluene-3-sulphonic acid
- EC Number:
- 201-837-6
- EC Name:
- 4-amino-6-chlorotoluene-3-sulphonic acid
- Cas Number:
- 88-51-7
- Molecular formula:
- C7H8ClNO3S
- IUPAC Name:
- 2-amino-4-chloro-5-methylbenzene-1-sulfonic acid
- Test material form:
- solid - liquid: suspension
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- 7.500 mg/kg
- No. of animals per sex per dose:
- 10
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- other:
- Effect level:
- > 7 500 mg/kg bw
- Remarks on result:
- other: 1 death on 4th day after dosing; diarrhea, stained and wet perineal area, stained face, slight to moderate weight loss observed
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: other: Interpretation of literature data
- Conclusions:
- Based on the test results (1 death of 10 rats at a single dosage of 7.500 mg/kg bw ) the substance does not have to be classified according to Regulation (EC) no. 1272/2008, Directive 67/548/EEC respectively
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