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EC number: 203-809-9 | CAS number: 110-86-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This is a limited case series of human sensitisation events as reported by medical personnel in a journal expressly dedicated to case reports. Neither the hazard nor the risk of dermal sensitisation can be determined from this data.
Data source
Reference
- Reference Type:
- publication
- Title:
- Narrow spectrum of cross-sensitization with pyridine derivatives
- Author:
- Sasseville D, Kwong P and Yu K
- Year:
- 1 998
- Bibliographic source:
- Contact Dermatitis, 38: 212-214
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- case report
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- This is an observational report of case series.
- GLP compliance:
- no
Test material
- Reference substance name:
- Pyridine
- EC Number:
- 203-809-9
- EC Name:
- Pyridine
- Cas Number:
- 110-86-1
- Molecular formula:
- C5H5N
- IUPAC Name:
- pyridine
- Details on test material:
- A large series of substances was tested, including: 2-aminopyridine, 2,6-diaminopyridine, 2,3-diaminopyridine, 3-pyridine carboxylic acid, 5-hydroxy-6-methyl-3,4-pyridinemethanol HCl, zinc bis(pyridinethiol-1-oxide), 2,6-diamino-3-phenylazopyridine, 2-[benzyl(2-dimethylaminoethyl)amino]pyridine, N'-2-pyridylsulfanilamide, 5-[p-(2-pyridylsulfamoyl)phenylazo]salicylic acid, pyrimidine, 2-aminopyrimidine, 2-sulfanilamidopyrimidine Ag, pyrazine, 2-aminopyrazine, and pyridazine.
Constituent 1
Method
- Type of population:
- other: patients with dermatology problems
- Ethical approval:
- not specified
- Subjects:
- 5 adults
- Route of administration:
- dermal
- Details on study design:
- These are the same patients who served as control subjects in the 1996 study of dermal sensitisation to the chemicals used by a chemist who experienced a severe dermal exposure episode. In the 1996 study, 4 of 5 control subjects were sensitised to one or more pyridine derivatives. To illuminate their cross-reaction spectrum, they underwent patch testing with an extended series of chemicals that included pyridine, pyridazine, pyrimidine and pyrazine compounds. Some of these substances were bought from Aldrich Chemical Company, while others were obtained from the pharmaceutical industry. Various dilutions were prepared and patch tests were conducted in the usual manner.
Results and discussion
- Results of examinations:
- No positive reaction was seen by any of the subjects.
Applicant's summary and conclusion
- Conclusions:
- In a case series of 5 subjects who previously demonstrated dermal sensitisation to pyridine compounds, all patch test results to additional pyridine derivatives were negative. It appears that the cross-sensitisation spectrum of pyridine derivatives is narrow.
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