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EC number: 249-109-7 | CAS number: 28629-66-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1978
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Protocol that complies with scientifically accepted methods, and is sufficiently detailed.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Section 1500.3 – Federal Hazardous Substance and Article, Administration and Enforcement Regulation, Federal Register, Vol. 38, No. 187, p. 27014, 27 September 1973, Section (c) (2) (i).
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Zinc bis(O,O-diisooctyl) bis(dithiophosphate)
- EC Number:
- 249-109-7
- EC Name:
- Zinc bis(O,O-diisooctyl) bis(dithiophosphate)
- Cas Number:
- 28629-66-5
- Molecular formula:
- Too complex
- IUPAC Name:
- zinc bis(O,O-diisooctyl) bis(dithiophosphate)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Sherman-Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
Source: No data available.
Age at study initiation: No data available.
Weight at study initiation: average weight between 200~300 g.
Fasting period before study: Feed was withheld overnight prior to dosing.
Housing: No data available.
Diet: ad libitum
Water: ad libitum
Acclimation period: No data available.
ENVIRONMENTAL CONDITIONS
Temperature (°C): No data available.
Humidity (%):No data available.
Air changes: No data available.
Photoperiod: No data available.
IN-LIFE DATES: From 06/06/1978 To 6/20/1978.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 1,000, 2,000, 4,000, 8,000, and 16,000 mg/kg bw
- No. of animals per sex per dose:
- 5/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data available.
- Necropsy of survivors performed: gross necropsies were performed.
Results and discussion
- Preliminary study:
- not applicable
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 3 200 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 2 000 - <= 5 300
- Mortality:
- 1000 mg/kg/bw:
Number of animals= 5; number of deaths: 0
2000 mg/kg/bw:
Number of animals= 5; number of deaths 2
4000 mg/kg/bw:
Number of animals = 5; number of deaths 2
8,000 mg/kg/bw:
Number of animals = 5; number of deaths 5
16,000 mg/kg/bw:
Number of animals = 5; number of deaths 5 - Clinical signs:
- other: All animals died in the high dose group. In the low dose group, all animals appeared ruffled up to 24 h after treatment, but appeared normal thereafter. In the low dose group, 1/5 female died on day 6; 2/5 females exhibited diarrhea, and 1/5 exhibited
- Gross pathology:
- No gross abnormalities were noted in all animals (either found dead during the study or in the animals necropsied at the conclusion of the study).
Any other information on results incl. tables
Table 1. Results
Dose (mg/kg) |
Body weight |
Mortality (dead/total No.) |
Observation |
|
Initial |
Final |
|||
1,000 |
260 |
290 |
0/5 |
2 h: lethargic and depressed 24 h: normal |
2,000 |
250 |
270 |
2/5
|
30’: depressed 1 h: quite lethargic 3~4 h: semi-comatose 12~18 h: death occurred. 7 d: normal. |
4,000 |
250 |
275 |
2/5 |
|
8,000 |
260 |
- |
5/5 |
3 h: comatose < 12 h: death occurred. |
16, 000 |
250 |
- |
5/5 |
Gross pathologic examination revealed nothing remarkable.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- The test article, when administered as received to male Sherman-Wistar rats, had an acute oral LD50 of 3,200 mg/kg bodyweight with 95% confidence limit of from 2,000 to 5,300 mg/kg bodyweight.
- Executive summary:
A single dose of the undiluted test material was administered intragastrically to 5 groups of fasted male albino rats (Sherman-Wistar strain) at each treatment level (1,000, 2,000, 4,000, 8,000, and 16,000 mg/kg bw). The animals were observed for signs of toxicity or behavioral changes during the 14 day observation period. Individual weights were recorded on the day of dosing and at termination. All animals died in the 8,000 mg/kg (~ 48 h after treatment) and 16,000 mg/kg (~ 24 h after treatment) dose groups. No mortality in the remaining groups.Gross autopsies were performed and nothing remarkable was revealed.
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