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EC number: 232-164-6 | CAS number: 7789-41-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Calcium bromide
- EC Number:
- 232-164-6
- EC Name:
- Calcium bromide
- Cas Number:
- 7789-41-5
- Molecular formula:
- CaBr2
- IUPAC Name:
- calcium bromide
- Details on test material:
- White powder, stored at room temperature over silica gel.
For the purpose of this study the test material was used as supplied.
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- The animal was housed in a suspended metal cage. Free access to mains drinking water and food was allowed throughout the study. The animal room was maintained at a temperature of 17-20C and relative humidity of 56-66%. The rate of air exchange was approximately 15 changes per hour and the lightning was controlled by a time switch to give 12 hours light and 12 hours darkness.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The left eye remained untreated.
- Amount / concentration applied:
- A volume of 0.1 ml of test material, which was found to weigh approximately 89.7 mg was used.
- Duration of treatment / exposure:
- Single instillation of 0.1 ml test substance; eyes were unwashed for 24 hours.
- Observation period (in vivo):
- 1 and 24 hours
- Number of animals or in vitro replicates:
- 1
- Details on study design:
- No further details
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Time point:
- other: 1 hour
- Score:
- 41
- Irritation parameter:
- overall irritation score
- Time point:
- other: 24 hours
- Score:
- 61
- Irritant / corrosive response data:
- No further details
- Other effects:
- Transcluent corneal opacity, iridial inflammation, severe conjubctival irritation and sloughing of the cornea with petechial haemorrhage of the lower conjunctival membrane and an area of possible necrosis over this area and the nictitating membrane were noted in the treated eye at the 1 and 24-hour observations.
A blood stained discharge was noted at the 24-hour observation and the animal was killed for humane reasons in accordance with current UK Government Home Office guidelines and Safepharm Company policy.
Any other information on results incl. tables
No further details
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test material, calcium bromide, produced a maximum total score of 61.0 and was considered to be at least a severe irritant (class 6 on a 1 to 8 scale) to the rabbit eye according to a modified Kay and Calandra classification system (based on rabbit only).
The test material produces positive criteria in the treated rabbit according to EU labeling regulations and was considered to be IRRITANT to the rabbit eye. It is reasonable to assume the symbol "Xi" and highest risk phrase R 41 "risk of serious damage to the eyes" are therefore required.
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