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EC number: 214-317-9 | CAS number: 1120-71-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1992-03-23 to 1992-04-05
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study without analytics according to OECD 203
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- yes
- Remarks:
- , no analytical dose verification
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: required amounts of the test substance were placed in a 1 L glass cylinder and made up to 1 L with water and added to 9 L of test water. Highest concentration of 1000 mg/L (for the preliminary test) was prepared directly by dissolving test item in the final volume of 10 L dechlorinated tap water
- Controls: Blank control with test medium only
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): none
- Stock solution: prepared directly by dissolving test item in the final volume of 10 L dechlorinated tap water.
- Evidence of undissolved material (e.g. precipitate, surface film, etc): none - Test organisms (species):
- Leuciscus idus
- Details on test organisms:
- TEST ORGANISM
- Common name: Golden orfe
- Source: Fischzucht Eggers / D-2354 Hohenwestedt
- Length at study initiation (length definition, mean, range and SD): 5.9 cm (mean of 20 fish
- Weight at study initiation (mean and range, SD): 2.22 g (mean of 20 fish)
- Method of holding:
- temperature: 18 ± 2.0 °C
- oxygen: at least 80% of air saturation (ca. 8.0 mg O2/L)
- pH: 7.0 - 8.5
- hardness: 14 °dH
- light: 16h daily; intensity: 600-800 lux
- feeding: once daily with trout pellets
- Feeding during test: none
ACCLIMATION
- Acclimation period: minimum of 14 days prior to test initiation
- Acclimation conditions (same as test or not): no (250 L glass container, flow-through conditions and permanent aeration) - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- 14°dH
- Test temperature:
- 18. 0 - 19.0°C
- pH:
- 8.11 - 8.32
- Dissolved oxygen:
- > 60%
(9.6 - 11 mg/L O2) - Nominal and measured concentrations:
- Nominal test substance concentrations: 10, 18, 32, 56, and 100 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: Glass aquaria of 12 liters
- Aeration: continuous aeration using a membrane pump system and pasteur pipettes for contact with test medium
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- No. of vessels per vehicle control (replicates): 1
- Biomass loading rate: 10 L for 5 fish
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Dechlorinated tap water (from SG dechlorination system)
- Intervals of water quality measurement: Daily
OTHER TEST CONDITIONS
- Photoperiod: 16 hours daily (600 - 800 Lux)
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : Mortality, Symptoms
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 1.78 (geometric series)
- Range finding study
- Test concentrations: 0.1, 1, 10, 100 and 1000 mg/L
- Results used to determine the conditions for the definitive study: LC100 (96 h): 100 mg/L, LC0 (96 h): 10 mg/L - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 32 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 72.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 32 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- - Behavioural abnormalities: None
- Mortality of control: None
- Other adverse effects control: None
- Abnormal responses: None
- Any observations (e.g. precipitation): None - Reported statistics and error estimates:
- 48 - 96 h LC50 values determined graphically as calculation of LC50 value by means of Probit analysis according to Finney was not feasible.
- Sublethal observations / clinical signs:
Due to the distribution of the data, the calculation of the LC50 values by means of the Probit analysis according to Finney was not feasible. Therefore, the 48 - 96 h LC50 was determined graphically.
Table: Mortality in preliminary test
Conc. Mg/L
1000
100
10
1
0.1
control
Mortality
%
%
%
%
%
%
2-4 h
0
0
0
0
0
0
24 h
100
40
0
0
0
0
48 h
100
100
0
0
0
0
72 h
100
100
0
0
0
0
96 h
100
100
0
0
0
0
Table: Mortality in main test
Conc. Mg/L
100
56
32
18
10
control
Mortality
%
%
%
%
%
%
2-4 h
0
0
0
0
0
0
24 h
0
0
0
0
0
0
48 h
100
10
0
0
0
0
72 h
100
10
0
0
0
0
96 h
100
10
0
0
0
0
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- April - May 1996
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: OECD Guideline Study performed in compliance with the UK Principles of Good Laboratory Practice, no analytical monitoring
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: The test solutions were prepared separately by adding the required amount of test substance to dechlorinated tap water. - Test organisms (species):
- Leuciscus idus
- Details on test organisms:
- TEST ORGANISM
- Common name:Juvenile golden orfe.
- Source:Fish were obtained from Xotic Fish Centre, Alfreton, Derbyshire
- Length at study initiation (length definition, mean, range and SD): 5.4 cm (SD: 0.3)
- Weight at study initiation (mean and range, SD): 1.54 g (SD: 0.38)
ACCLIMATION
- Acclimation period: 1 week
- Acclimation conditions (same as test or not): 21± 1 °C >=8.3 mg O2/L
- Type and amount of food during acclimation:Tetramin flake food.
- Feeding frequency during acclimation:feeding was stopped 48 hours prior to test start.
- Health during acclimation (any mortality observed): no mortality observed - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- 100 mg/L as CaCO3
- Test temperature:
- 20.0 - 20.5
- pH:
- 6.2 - 7.9 (at concentrations 100 - 320 mg/L)
3.6 (at concentration 560 mg/L)
2.6 (at concentration 1000 mg/L) - Dissolved oxygen:
- 7.9 - 8.0 mgO2/L
- Nominal and measured concentrations:
- Nominal: 100 mg/L, 180 mg/L, 320 mg/L, 560 mg/L and 1000 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: glass aquaria (20 L)
- Type (delete if not applicable): covered to reduce evaporation
- Material, size, headspace, fill volume:
- Aeration: yes
- Renewal rate of test solution (frequency/flow rate): daily
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- Biomass loading rate: 0.77 g bodyweight/L
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Tap water dechlorinated by passage through an activated carbon filter.
- Behavioural abnormalities:
OTHER TEST CONDITIONS
- Adjustment of pH:
- Photoperiod: 16:8 h day-night regime
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
Mortality and adverse reactions at 3, 6, 24, 48, 72 and 96 hours
TEST CONCENTRATIONS
- Range finding study
- Test concentrations: 1, 10, 100 and 1000 mg/L
- Results used to determine the conditions for the definitive study: Mortalities observed at 1000 mg/L - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 420 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 320 - 560 mg/L
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 180 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- - Behavioural abnormalities: swimming at the surface at concentrations > 180 mg/L.
- Sublethal observations / clinical signs:
Cumulative mortality
Nominal substance concentrations [mg/L] 3 h 6 h 24 h 48 h 72 h 96 h 0 0 0 0 0 0 0 100 0 0 0 0 0 0 180 0 0 0 0 0 0 320 0 0 0 0 0 0 560 6 10 10 10 10 100 1000 10 10 10 10 10 100
Referenceopen allclose all
Description of key information
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 72.5 mg/L
Additional information
The acute toxicity on fish was tested for the parent substance 1,3 -propanesultone and for the product of hydrolysis 3-hydroxypropanesulphonic acid. Due to the rapid hydrolysis testing of the parent substance 1,3-propanesultonewill ultimately result in an exposure to the product of hydrolysis. Therefore the available tests were assessed in a weight of evidence approach.
The acute toxicity to Leuciscus idus was tested in a guideline study following OECD 203, conducted with the test item 3-hydroxypropanesulphonic acid. The fish were exposed to nominal substance concentrations of 100 mg/L, 180 mg/L, 320 mg/L, 560 mg/L and 1000 mg/L. The test was set up in a semi-static test design with a daily renewal rate of the tested concentrations. After a total exposure period of 96 hours a LC50 (96 h) of 420 mg/L based on nominal concentrations was determined.
The acute toxicity of 1,3-propanesultone was tested in a static test according to OECD 203. Fish of the species Leuciscus idus were exposed to nominal test item concentrations of 0 (control), 10, 18, 32, 56 and 100 mg/L. The 96-h LC50 was 72.5 mg/L.
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