N,N'-bis(1,3-dimethylbutylidene)-2,2'-iminobis(ethylamine)

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

Not reported

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

Study conducted in accordance with generally accepted scientific principles, with incomplete reporting or methodological deficiencies. This reference does not provide a full report with regard to the methods used in this study. Basic key information is reported, although the method does not correspond to current recognised guidelines.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1981

Report date:

1981

Materials and methods

Test guideline

Qualifier:

no guideline followed

Deviations:

not applicable

Principles of method if other than guideline:

0.06 mL of the undiluted test material was applied to the skin of New Zealand White rabbits and left uncovered. The effects evaluated after 24 hours.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

N,N'-bis(1,3-dimethylbutylidene)-2,2'-iminobis(ethylamine)

EC Number:

234-205-3

EC Name:

N,N'-bis(1,3-dimethylbutylidene)-2,2'-iminobis(ethylamine)

Cas Number:

10595-60-5

Molecular formula:

C16H33N3

IUPAC Name:

N-(1,3-dimethylbutylidene)-N'-{2-[(1,3-dimethylbutylidene)amino]ethyl}ethane-1,2-diamine

Test material form:

other: watery liquid

Details on test material:

- Physical details: light amber, watery liquid with a highly noticeable odour.
- Storage conditions: ambient room temperature

Test animals

Species:

rabbit

Strain:

New Zealand White

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Diet (e.g. ad libitum): ad libitum Wayne diet
- Water (e.g. ad libitum): ad libitum

Test system

Type of coverage:

open

Preparation of test site:

clipped

Vehicle:

unchanged (no vehicle)

Controls:

not specified

Amount / concentration applied:

0.06 mL

Duration of treatment / exposure:

24 hours

Number of animals:

5

Details on study design:

The test material was applied to the bellies of the rabbits.

Results and discussion

In vivo

Irritant / corrosive response data:

At 24 hours, moderate capillary injection was seen in a single rabbit; marked capillary injection was seen in a further rabbit. Two rabbits exhibited moderate erythema and marked erythema could be seen in 1 animal.

Applicant's summary and conclusion

Conclusions:

The test material was seen to produce minor irritation to the skin of the New Zealand White rabbit under the conditions of this study.

Executive summary:

The potential of the test material to cause skin irritation was investigated in a test in which 0.06mL of the undiluted test material was applied to the clipped, intact belly skin of New Zealand White rabbits and the effects evaluated after 24 hours.

The test material was seen to produce minor irritation under the conditions of this study. However a lack of data prevents definitive classification of the test material in accordance with EU criteria.