Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-765-0 | CAS number: 110-41-8
Endpoint summary
Administrative data
Description of key information
The test substance was assessed for skin irritation with rabbits dermally exposed to the test material for 24 hr. The results of the study showed that the test material should be classified as a Category 2 skin irritant.
The test substance was assessed for eye irritation according to OECD guideline 405. The results of the study showed that the test material is not irritating to eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The test substance was assessed for skin irritation with rabbits dermally exposed to the test material for 24 hr. The study was performed in two parts. Initially 4 rabbits were exposed to the unchanged test substance and observed over a 10-day period; in the second part, 3 rabbits were exposed to the unchanged test substance and were observed for 14 days. Erythema and oedema were observed in most of the animals tested in both groups with a number showing reactions that were not reversible within the observation period. It was concluded that the test material should therefore be classified as a Category 2 skin irritant. A supporting study using guinea pigs was also performed and showed that under the conditions of the test, the test was found to be mildly irritating to guinea pigs at 5 % concentration.
The test substance was assessed for eye irritation according to OECD guideline 405. Observations showed no corneal or iris irritation. Mild scores were recorded for conjunctival redness and chemosis, but these were reversible within the observation period. The results of the study showed that the test material is not irritating to eyes.
Effects on skin irritation/corrosion: irritating
Justification for classification or non-classification
According to the results of the key study the substance should be classified as a skin irritant category 2 in accordance with Regulation (EC) No. 1272/2008.
According to the results of the key study the substance is not classified as an eye irritant in accordance with Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
