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EC number: 271-802-8 | CAS number: 68608-82-2 A complex combination of hydrocarbons obtained by the alkylation of benzene with ethene. It consists primarily of ethylbiphenyls, diethylbenzenes with lesser amounts of butylbenzenes and polyethylbenzenes.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not applicable
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: study well reported but results not reported according to current guideline criteria.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-5 (Acute Dermal Irritation)
- Qualifier:
- according to guideline
- Guideline:
- other: FIFRA Volume 43, #143 of the Federal Register, Aug. 22, 1978, Part 163.81-5. (EPA, Pesticide Programs: Proposed Guidelines for Registering Pesticides in the U.S.; Hazard Evaluation: Humans and Domestic Animals. Primary Dermal Irritation Study).
- Qualifier:
- according to guideline
- Guideline:
- other: TSCA Volume 44, No.145 of the Federal Register, July 26, 1979, Part 772.112-25. (Environmental Protection Agency, Proposed Health Effects Test Standard for Toxic Substances Control Act Test Rules. Primary Dermal Irritation Study).
- Qualifier:
- according to guideline
- Guideline:
- other: TSCA (Toxic Substances Control Act) : Health Effects Test Guidelines, Office of Toxic Substances, Office of Pesticide and Toxic Substances, United States Environmental Protection Agency, August 1982, Acute Exposure, Primary Dermal Irritation .
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- not specified
Test material
- Details on test material:
- Test substance: MCS-2170
Physical state: Yellow Liquid
Reference Number: NBP-2532690-B
Stored at Room Temperature
Density 0.97 g/ml
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hazleton-Dutchland Laboratory Animals Denver, Pennsylvania USA
- Age at study initiation: young adults
- Weight at study initiation:
- Housing: Individually housed during study in stainless steel cages
- Diet: ad libitum Purina Rabbit Laboratory Chow #5326
- Water: ad libitum
- Acclimation period: 36 or 37 days
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 60-70 Deg Farenheit
- Humidity (%): 30-70%
- Photoperiod (hrs dark / hrs light): 12h day/night cycle
Test system
- Type of coverage:
- other: 4-hour interval: semi-occlusive covering. 24-hour interval: occlusive covering.
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit):0.5 ml/site
- Duration of treatment / exposure:
- Single 4- or 24-hour exposure followed by a 7-14 day observation period.
- Observation period:
- Observations were made approximately 0, 4, 4.5, 28, 28.5, 52 and 72 hours then as necessary for Days 3-14, 2 times per day.
- Number of animals:
- Six rabbits for the 4-hour Exposure 24-hour Exposure
- Details on study design:
- TEST SITE
- Area of exposure: 4 sites, clipped intact skin of the back, on each rabbit
- % coverage: 10%
- Type of wrap if used: 4-hour exposure, Semi-occlusive. The appropriate amount of the test material was applied beneath a gauze square, 1"x1", placed directly on each of two test sites nearest the head of the rabbits and held in place with non-irri tating tape. Gauze was then wrapped around the animal and covered with porous tape, to semi-occlude the test sites.
24-hour exposure, Occlusive. The appropriate amount o f the test material was applied beneath a gauze square, 1 " x 1" , placed directly on each of two test sites posterior to the 4-hour sites and held in place with non-i rritating tape. Plastic sheeting was then wrapped around the animal and secured with tape to retard evaporation and keep the test material in contact with the skin without undue pressure. (The plastic and tape were placed so as not to interfere with the 4-hour sites).
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Following exposure, the wrappings and gauze squares were removed and the test site was gently wiped free of excess test material using water and gauze.
- Time after start of exposure: 4 hours or 24 hours exposures
SCORING SYSTEM: Draize method (Draize, J.H. 1959. The Appraisal of Chemicals in Foods, Drugs, and Cosmetics, p, 48. Association of Food and Drug Officials of the United States, Austin, Texas.)
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24 hour
- Score:
- 4.6
- Max. score:
- 8
- Reversibility:
- fully reversible within: 7 days
- Irritant / corrosive response data:
- Irritation was generally mild to moderate at the sites exposed for 4 hours under a semi-occlusive covering and moderate to severe at the sites exposed for 24 hours under an occlusive covering. Superficial tissue damage (transient or epidermal necrosis) was seen at one of the 4 hour sites in two o f the six animals and at one or both 24 -hour sites in all animals. All animals were free of significant irritation within 7 to 14 days after test material application.
Any other information on results incl. tables
SUMMARY OF DERMAL IRRITATION (INCIDENCE OF TISSUE DESTRUCTION, TIME TO RECOVERY)
Animal Number |
Site |
Tissue Destruction |
Time to Clear |
4-HOUR EXPOSURE |
|||
4988 F |
RF |
None |
Day 7 |
|
LF |
None |
Day 7 |
|
|
|
|
4986 F |
RF |
None |
Day 7 |
|
LF |
Epidermal |
Day 10 |
|
|
|
|
4987 M |
RF |
None |
Day 7 |
|
LF |
None |
Day 7 |
|
|
|
|
4974 F |
RF |
None |
Day 10 |
|
LF |
None |
Day 7 |
|
|
|
|
4962 F |
RF |
None |
Day 10 |
|
LF |
None |
Day 10 |
|
|
|
|
4965 M |
RF |
None |
Day 14 |
|
LF |
Subepidermal |
Day 14 |
24-HOUR EXPOSURE |
|||
4988 F |
RB |
Epidermal |
Day 10 |
|
LB |
Epidermal |
Day 10 |
|
|
|
|
4986 F |
RB |
Epidermal |
Day 14 |
|
LB |
None |
Day 10 |
|
|
|
|
4987 M |
RB |
Epidermal |
Day 10 |
|
LB |
None |
Day 10 |
|
|
|
|
4974 F |
RB |
Epidermal |
Day 10 |
|
LB |
Epidermal |
Day 10 |
|
|
|
|
4962 F |
RB |
Epidermal |
Day 14 |
|
LB |
None |
Day 10 |
|
|
|
|
4965 M |
RB |
Epidermal |
Day 10 |
|
LB |
Epidermal |
Day 10 |
Time clear represents interval at which significant dermal irritation was no longer present. If some
irritation remained at termination of the study (Day 14), no interval is indicated.
RF=RightFront; LF=Left Front; RB=Right Back; LB=Left Back.
Irritation was generally mild to moderate at the sites exposed for 4 hours under a semi-occlusive covering and moderate to severe at the sites exposed for 24 hours under an occlusive covering. Superficial tissue damage (transient or epidermal necrosis) was seen at one of the 4 hour sites in two of the six animals and at one or both 24 -hour sites in all animals. All animals were free of significant irritation within 7 to 14 days after test material application.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- The primary irritation index for the 24-hour exposures was 4.6.
- Executive summary:
Irritation was generally mild to moderate at the sites exposed for 4 hours under a semi-occlusive covering and moderate to severe at the sites exposed for 24 hours under an occlusive covering. Superficial tissue damage (transient or epidermal necrosis) was seen at one of the 4 hour sites in two of the six animals and at one or both 24 -hour sites in all animals. All animals were free of significant irritation within 7 to 14 days after test material application.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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