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Diss Factsheets
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EC number: 222-883-3 | CAS number: 3648-18-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
BCF <100, dioctytin bis(2-ethylhexyl thioglycolate), OECD 305, EU Method C.13, Bouwman 2010
Key value for chemical safety assessment
- BCF (aquatic species):
- 100 dimensionless
Additional information
The key study was performed in line with GLP and in accordance with standardised guidelines OECD 305 and EU Method C.13. The study was performed on the surrogate substance dioctyltin bis(2-ethylhexyl thioglycate); like all octyltin compounds, this is anticipated to hydrolyse very rapidly in water. The fish in the study are therefore expected to have been exposed to the same organotin species that would occur if the test had been performed using the registration substance as the test essentially measures the dioctyltin species.
The bioconcentration of the test material in rainbow trout exposed to 0.25 and 2.5 µg/L for 30 days in a flow-through system was determined to be 1294 and 99 respectively based on measured dioctyltin. The high BCF value found at the 0.25 µg/L concentration was due to the limitations in the sensitivity of the analytical methods employed in the study and could not be further improved. Based on the result found at the highest concentration tested, the BCF is at least less than 100 and therefore the substance is not expected to bioconcentrate.
The study was performed to a good standard with a sufficient level of detail to assess the quality of the results. As such it was assigned a reliability score of 2 due to being used in a read across capacity using the principles for assessing data quality as set out in Klimisch (1997) and considered suitable as an accurate reflection of the test material.
Two disregarded studies, Recommendation for classification dossier (2005) and IUCLID Dataset (2006), on the read across material n-dioctyltin oxide were included for completeness as both are in the public domain. The studies were deemed unsuitable as the result was derived using calculation software not validated for organometallic substances and reported in a secondary source.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.