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Toxicological information

Toxicity to reproduction: other studies

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Administrative data

Endpoint:
toxicity to reproduction: other studies
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1971

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Female Wistar rats were co-housed overnight in cages with males and examined for sperm the next morning. After confirmation of pregnancy, females were housed 2 animals/cage, and allowed commercial chow and water ad libitum. Benzoic acid was not the primary test article in this study, but was used to prolong clearance of salicylic acid. To this end, a separate group of females received benzoic acid alone on GD 9. Animals were euthanized on GD 20.
GLP compliance:
not specified
Type of method:
in vivo

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Purity: not specified Batch No.: NCEL No. 817
Specific details on test material used for the study:
Not stated.

Test animals

Species:
rat
Strain:
Wistar
Sex:
female
Details on test animals and environmental conditions:
Animals were housed in metabolism cages.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
CMC (carboxymethyl cellulose)
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
Single exposure.
Frequency of treatment:
Single exposure.
Duration of test:
Benzoic acid was administered on GD 9.
Doses / concentrations
Dose / conc.:
510 mg/kg bw (total dose)
Remarks:
Benzoic acid was given by gavage to impact salicylic acid clearance.
No. of animals per sex per dose:
7 females in the "benzoic acid alone" group.

Results and discussion

Applicant's summary and conclusion

Conclusions:
Although benzoic acid was not the primary subject of this study, one group of 7 females was treated with 510 mg/kg bw benzoic acid to prolong clearance of salicylic acid. Malformations and resorption rates after benzoic acid alone were comparable to those in control animals.
Executive summary:

Although benzoic acid was not the primary subject of this study, one group of 7 females was treated with 510 mg/kg bw benzoic acid to prolong clearance of salicylic acid. Malformations and resorption rates after benzoic acid alone were comparable to those in control animals.