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EC number: 616-391-1 | CAS number: 76812-02-7
Vapour pressure
Administrative data
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Study initiation: 24.09.1997 / Starting date: 18.02.1998 / End of laboratory investigations: 19.02.1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according to international guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- GLP compliance:
- yes
- Type of method:
- effusion method: vapour pressure balance
Test material
- Reference substance name:
- 4-[4-[4-(Hydroxydiphenylmethyl)-1-piperidinyl]-1-oxobutyl]-α,α-dimethyl-ethyl ester benzeneacetic acid
- EC Number:
- 616-391-1
- Cas Number:
- 76812-02-7
- Molecular formula:
- C34 H41 N O4
- IUPAC Name:
- 4-[4-[4-(Hydroxydiphenylmethyl)-1-piperidinyl]-1-oxobutyl]-α,α-dimethyl-ethyl ester benzeneacetic acid
- Reference substance name:
- 4-(4-(4-Hydroxydiphenylmethyl)-1-piperidinyl)-1-oxobutyl- alpha,alphadimethylbenzeneacetic acid ethyl ester
- IUPAC Name:
- 4-(4-(4-Hydroxydiphenylmethyl)-1-piperidinyl)-1-oxobutyl- alpha,alphadimethylbenzeneacetic acid ethyl ester
- Details on test material:
- - Name of test material (as cited in study report): Fexofenadone-Ethylester
- Analytical purity: 98.65 % (w/w)
- Code-No.: HOE CG 0529 OY ZD99 0001
- Lot/batch No.: TAM 40-96-13 dated 27.08.1996
- Storage condition of test material: 2 Years in a refrigerator Exclusion of moisture. (information by the producer)
- Certificate No., date: dated 19.08.1997
- Expiration date of the certificate: August 1998
Constituent 1
Constituent 2
Results and discussion
Vapour pressure
- Temp.:
- 25 °C
- Vapour pressure:
- 0 hPa
Any other information on results incl. tables
The vapour pressure was first measured at a temperature of 22.2°C. At 115.3°C the vapour pressure of the test substance was above the lower measuring limit.
The following table shows the measured pressure data at the corresponding temperatures.
| Temperature [°C] | Vapour pressure [hPa] |
| 115.3 | 9.2 x 10^-6 |
| 122.4 | 2.3 x 10^-5 |
| 137.1 | 1.1 x 10^-4 |
| 146.5 | 1.8 x 10^-4 |
| 150.8 | 5.3 x 10^-4 |
| 151.1 | 4.3 x 10^-4 |
The logarithm of vapour pressure as a function of the inverse of temperature (1/T, T in Kelvin) is determined :
log (p/hPa) = A + B/C+T (°C)
A = 14.41228
B= -7548.05
C = 273.15
Applicant's summary and conclusion
- Conclusions:
- Approximate value for 25°C is 1.10^-11 hPa.
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