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EC number: 204-200-0 | CAS number: 117-61-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
From the available data, it can be concluded that the chemical benzidine-2,2'-disulphonic acid is unlikely to exhibit acute toxicity by the oral, inhalation and dermal route
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- no
- Test type:
- standard acute method
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- not specified
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 400 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: sex details not given
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 value as predicted by the QSAR model was found to be 3400 mg/Kg bw of Rat by the oral route. This value suggests that benzidine-2,2'-disulphonic acid shall not exhibit acute toxicity by the oral route within this concentration range
- Executive summary:
The LD50 value as predicted by the QSAR model was found to be 3400 mg/Kg bw of Rat by the oral route. This value suggests that benzidine-2,2'-disulphonic acidshall not exhibit acute toxicity by the oral route within this concentration range
Reference
The prediction was based on dataset comprised from the following descriptors: LD50
Estimation method: Takes average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
((((("a" and ("b" and ( not "c") ) ) and "d" ) and "e" ) and "f" ) and ("g" and "h" ) )
Domain logical expression index: "a"
Referential boundary: The target chemical should be classified as Anilines (Acute toxicity) by US-EPA New Chemical Categories
Domain logical expression index: "b"
Referential boundary: The target chemical should be classified as No alert found by Protein binding by OECD
Domain logical expression index: "c"
Referential boundary: The target chemical should be classified as Acylation OR Acylation >> Direct Acylation Involving a Leaving group OR Acylation >> Direct Acylation Involving a Leaving group >> Acetates OR SNAr OR SNAr >> Nucleophilic aromatic substitution OR SNAr >> Nucleophilic aromatic substitution >> Activated halo-benzenes by Protein binding by OECD
Domain logical expression index: "d"
Referential boundary: The target chemical should be classified as High (Class III) by Toxic hazard classification by Cramer (original)
Domain logical expression index: "e"
Referential boundary: The target chemical should be classified as Bioavailable by Lipinski Rule Oasis
Domain logical expression index: "f"
Similarity boundary:Target: c1(-c2c(S(=O)(=O)O)cc(N)cc2)c(S(=O)(=O)O)cc(N)cc1
Threshold=50%,
Dice(Atom centered fragments)
Domain logical expression index: "g"
Parametric boundary:The target chemical should have a value of log Kow which is >= -4
Domain logical expression index: "h"
Parametric boundary:The target chemical should have a value of log Kow which is <= -1.41
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 400 mg/kg bw
- Quality of whole database:
- Since the model is considered relaible by OECD the predictions are expected to be reliable and have been used in the absence of experimental results
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- A method of Draize et al. (1944) was followed. Neat material was held in contact with clipped skin for 24h (occlusive) by a rubber sleeve. Prior to exposure the subjects are prepared by clipping the skin of the trunk free of hair. The sleeve is slipped onto the animal which is then placed in a comfortable but immobilized position in a multiple animal holder. The doses of liquids and solutions are calculated on tile basis of body weight and introduced under the sleeve.
- GLP compliance:
- no
- Test type:
- other: study of 1944 as per the then existing guidelines
- Limit test:
- yes
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 14 days
- Doses:
- - 3.9, 6.0 and 9.4 ml/kg bw in a preliminary range finding
no further details on single doses given - No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: blood morphology - Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 12 000 mg/kg bw
- Remarks on result:
- other: calculated from original data 10 ml/kg (density 1.194 g/ml)
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- An experimental LD50 value of > 12000 mg/kg bw in rabbit was obtained for the read-across chemical (CAS No 131-11-3). In the absence of test data for the target chemical (CAS No 117-61-3) it is assumed that given the 60% structural similarity of the analogue to the target, benzidine-2,2'-disulphonic acid is assumed to not exhibit acute toxicity by the dermal route
- Executive summary:
An experimental LD50 value of > 12000 mg/kg bw in rabbit was obtained for the read-across chemical (CAS No 131-11-3). In the absence of test data for the target chemical (CAS No 117-61-3) it is assumed that given the 60% structural similarity of the analogue to the target, benzidine-2,2'-disulphonic acid is assumed to not exhibit acute toxicity by the dermal route
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 12 000 mg/kg bw
- Quality of whole database:
- reliable with restriction
Additional information
From the available data, it can be concluded that the chemical benzidine-2,2'-disulphonic acid is unlikely to exhibit acute toxicity by the oral, inhalation and dermal route
Justification for selection of acute toxicity – oral endpoint
QSAR model considered relaible by OECD
Justification for selection of acute toxicity – inhalation endpoint
In accordance with column 2 of Annex VIII, testing by the inhalation route is appropriate only if exposure of humans via inhalation is likely taking into
account the vapour pressure of the substance. Since the vapour pressure of this chemical is very low (0.000000000000000431 Pa), there is least likelihood of exposure via the inhalation route. Therefore, this end point was considered for waiver.
Justification for selection of acute toxicity – dermal endpoint
An experimental LD50 value of > 12000 mg/kg bw in rabbit was obtained for the read-across chemical (CAS No 131-11-3). In the absence of test data for the target chemical (CAS No 117-61-3) it is assumed that given the 60% structural similarity of the analogue to the target, benzidine-2,2'-disulphonic acid is assumed to not exhibit acute toxicity by the dermal route
Justification for classification or non-classification
The chemical benzidine-2,2'-disulphonic acid is unlikely to exhibit acute toxicity by the oral, inhalation and dermal route
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