Registration Dossier
Registration Dossier
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EC number: 203-757-7 | CAS number: 110-33-8
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
The PBT Assessment for Dihexyl adipate (CAS 110-33-8) is based on the criteria set out in the “Guidance on information requirements and chemical safety assessment, Chapter R.11: PBT Assessment” (ECHA, 2012d).
Persistence
Dihexyl adipate (CAS 110-33-8) is readily biodegradable according to a study following OECD guideline 301B (Clarke, 2012; 71% CO2 evolution after 28 d, the 10 -day window was passed). Thus, the test substance does not meet the screening criterion for persistency and it is not considered to be P or vP.
Bioaccumulation
The bioaccumulation potential of Dihexyl adipate (CAS 110-33-8) is expected to be low. The substance is rapidly metabolised and excreted by organisms and thus an accumulation is not expected. This is supported by calculated low BCF/BAF values using SRC BCFBAF v3.01 (BCF/BAF: 28.7 L/kg; Arnot-Gobas estimate, upper trophic). Thus the substance is not considered to be B or vB.
Toxicity
Dihexyl adipate (CAS 110-33-8) is considered to be not toxic. Studies on the acute toxicity determined no effects up to the limit of water solubility of the substance to fish, algae and aquatic invertebrates. A chronic toxicity is not expected since the substance is not persistent and has a low potential for bioaccumulation. Furthermore the substance is not classified for specific target organ toxicity, carcinogenicity, mutagenicity or reproductive and developmental toxicity in mammals (See Section 5.9). The criteria for “T” based on mammalian effects are therefore not met. Thus, the criteria set out in Annex XIII of Regulation (EC) No. 1907/2006 are not met and the substance is considered to be not T.
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