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EC number: 203-137-6 | CAS number: 103-71-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Several acute toxicity studies are available:
Acute oral toxicity: in the key study a LD50 = 887 mg/kg bw for rat
(male+female) was found, in another study a LD50 = 2500 - 2750 mg/kg bw
(male +female rats) was found and in a third study a LD50 = 1044 mg/kg
bw for male rats and a LD50 = 172 mg/kg bw for female rats was
determined. The reason for this discrepancy is unclear
Acute dermal toxicity: in one study a LD50 = ca. 5500 mg/kg bw for male
rats and a LD50 > 5500 mg/kg bw for female rats was determined, in other
studies on rabbits LD 50 values of > 2000 mg/kg bw or 7127 mg/kg bw
(male/female rabbits) was found.
In the key acute inhalation study a LD50 = 22 mg/m³ (4h) was determined.
The other studies were not regarded due to methodological deficiencies.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Six groups of 5 male and 10 female young adult Wister rats (average weight 175 g) each received per gavage a single dose of 100, 500, 1000, 1500, 2000 or 2500 µl/kg bw (= ca. 109.5, 547.5, 1095, 1642.5, 2190, 2737.5 mg/kg) of undiluted phenyl isocyanate. The animals were observed for mortality, body weight and clinical signs through day 14.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 100, 500, 1000, 1500, 2000 or 2500 µl/kg (= ca. 109.5, 547.5, 1095, 1642.5, 2190, 2737.5 mg/kg)
density = 1,095 kg/L (20 °C) - No. of animals per sex per dose:
- 5 male and 5 female animals/sex/dose
- Control animals:
- no
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 0.81 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 0.81 ml/kg bw = 887 mg/kg bw
- Mortality:
- Males: 0 (0.1 ml/kg bw), 2 (0.5 ml/kg bw), 3 (1.0 ml/kg bw), 4 (1.5 ml/kg bw), 4 (2.0 ml/kg bw), 5 (2.5 ml/kg bw)
Females: 0 (0.1 ml/kg bw), 2 (0.5 ml/kg bw), 2 (1.0 ml/kg bw), 3 (1.5 ml/kg bw), 4 (2.0 ml/kg bw), 5 (2.5 ml/kg bw) - Clinical signs:
- other: A single dose of 0.5 to 2.5 ml/kg bw caused in all animals weight reduction, anesthesia and decrease of the general condition. At a dose of 1.0 to 2.5 ml/kg bw cyanosis and disordered breathing was additionally observed. The symptoms occurred after 10 min
- Gross pathology:
- No data
- Other findings:
- No data.
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- For male and female rats a LD50 = 0.81 ml/kg bw = 887mg/kg bw was found. According to CLP classification criteria (Regulation (EC) No 1272/2008) a classification as Acute Tox. 4 is justified.
- Executive summary:
Six groups of 5 male and 10 female young adult Wister rats (average weight 175 g) each received per gavage a single dose of 100, 500, 1000, 1500, 2000 or 2500 µl/kg bw of undiluted phenyl isocyanate. The animals were observed for mortality, body weight and clinical signs through day 14.
Signs of intoxication were cyanosis, weight reduction, disordered breathing and a reduction of the general condition.
For male and female rats a LD50 = 0.81 ml/kg bw = 887mg/kg bw was found.
Reference
Signs of intoxication: Cyanosis, weight reduction, disordered breathing, reduction of general condition. No significant differences in male and female rats were observed.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 887 mg/kg bw
- Quality of whole database:
- Scientifically acceptable and sufficient documented.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- Seven groups of 5 male and 5 female rats were exposed nose/head only to vapours of 0, 0.7, 5.4, 15.2, 11.7, 27.9, 47.1 or 87.8 mg/m³ (analytical) phenyl isocyanate for 4 hours. The animals were observed for mortality, body weight and clinical signs through day 14. A gross pathological examination was performed on animals which died intercurrent or were killed after termination of the study.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Specific details on test material used for the study:
- Content: 99.9%
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- nose/head only
- Vehicle:
- air
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 0, 2, 19, 21, 31, 65, 83, 150 (nominal)
0, 0.7, 5.4, 15.2, 11.7, 27.9, 47.1 or 87.8 mg/m³ (analytical) - No. of animals per sex per dose:
- 5 rats/sex/dose
- Control animals:
- yes
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 0.022 mg/L air
- Based on:
- test mat.
- 95% CL:
- >= 0.019 - <= 0.027
- Exp. duration:
- 4 h
- Mortality:
- Males: 0 (control), 0 (0.7 mg/m³), 0 (5.4 mg/m³), 0 (15.2 mg/m³), 0 (11.7 mg/m³), 3 (27.9 mg/m³), 5 (47.1 mg/m³), 5 (87.8 mg/m³)
Females: 0 (control), 0 (0.7 mg/m³), 0 (5.4 mg/m³), 0 (15.2 mg/m³), 1 (11.7 mg/m³), 4 (27.9 mg/m³), 5 (47.1 mg/m³), 5 (87.8 mg/m³) - Clinical signs:
- other: Beginning at 0.005 mg/l phenyl isocyanate in the test atmosphere a concentration dependent irritation of the respiratory tract und long lasting respiratory discomfort was evident.
- Body weight:
- A significant influence on body weight gain was seen beginning with group 5 (11.7 mg/m³).
- Gross pathology:
- Lungs inflated and edematous. Rhinarium and intestinal mucosa reddened. Spleen, liver and kidneys pale.
- Other findings:
- A delayed mortality occurred. The median of survival was 9 days.
- Interpretation of results:
- Category 1 based on GHS criteria
- Conclusions:
- The LC50 was 0.022 mg/l (rat, male + female). According to CLP classification criteria (Regulation (EC) No 1272/2008) a classification as Acute Tox. 1 is justified.
- Executive summary:
Seven groups of 5 male and 5 female rats were exposed nose/head only to vapours of 0, 0.7, 5.4, 15.2, 11.7, 27.9, 47.1 or 87.8 mg/m³ (analytical) phenyl isocyanate for 4 hours. The animals were observed for mortality, body weight and clinical signs through day 14. A gross pathological examination was performed on animals which died intercurrent or were killed after termination of the study.
LC50 = 0.022 mg/l (rat, male + female). Beginning at 0.005 mg/l phenyl isocyanate in the test atmosphere a concentration dependent irritation of the respiratory tract und long lasting respiratory discomfort was evident. The delayed mortality was caused by an irritative lung damage.
The NOEL was 0.0007 mg/l phenyl isocyanate.
Reference
Beginning at 0.005 mg/l phenyl isocyanate in the test atmosphere a concentration dependent irritation of the respiratory tract und long lasting respiratory discomfort was evident. The delayed mortality were caused by an irritative lung damage.
The NOEL was 0.0007 mg/l phenyl isocyanate
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 22 mg/m³ air
- Quality of whole database:
- GLP guideline study.
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- Scientifically acceptable and sufficient documented.
Additional information
The results from available acute oral toxicity studies are quite inconsistent. By a weight of evidence consideration a LD50 = 887 mg/kg bw is considered for risk assessment.
The LD50 for dermal application on rats was > 2000 mg/kg bw.
In the key study for acute inhalation toxicity (4 h exposure) the LC50 is 22 mg/m³
Justification for classification or non-classification
For male and female rats an acute oral LD50 = 0.81 ml/kg bw = 887 mg/kg bw was found. According to CLP classification criteria (Regulation (EC) No 1272/2008) a classification as Acute Tox. 4 is justified.
The acute vapour inhalation LC50 was 22 mg/m³ (rat, male + female). According to CLP classification criteria (Regulation (EC) No 1272/2008) a classification as Acute Tox. 1 is justified.
The acute dermal LD50 was > 5000 mg/kg bw (rat, male + female). According to CLP classification criteria (Regulation (EC) No 1272/2008) a classification is therefore not justified.
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