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EC number: 416-740-6 | CAS number: -
Sediment toxicity
Administrative data
Link to relevant study record(s)
Description of key information
Sediment toxicity:
Short-term toxicity to sediment invertebrates: 14-day mortality and growth test in Hyalella azteca and Chironomus tentans- key study for read-across DIDP surrogate- did not cause toxicity.
Conclusion: Read-across results from the structurally related isomeric phthalate surrogate, namely, DIDP (CAS No. 68515-49-1) indicate that the submission substance is not expected to cause toxicity to sediment invertebrates at high sediment loading levels of greater than 3000 mg/kg
Key value for chemical safety assessment
Additional information
Data directly evaluating the sediment toxicity of the submission substance are not available. However, there are sufficient read-across short-term sediment toxicity data reported for the isomeric alkyl phthalate analogues such as diisodecyl phthalate (DIDP) (CAS No. 68515-49-1), which can provide some useful read-across assessment for terephthalate congener materials like the submission substance. From a structure activity relationship perspective, the long-chain alkyl phthalates and the corresponding long-chain terephthalates are chemically similar and related in that they are isomeric analogs of each other. From a toxicological perspective, one would expect terephthalates (i.e., 1,4-benzenedicarboxylic acid, diesters) to have similar toxicity to the corresponding phthalate materials (i.e., 1,2-benzenedicarboxylic acid, diesters) owing to their similar physical chemical characteristics (e.g., water insolubililty, log Kow, and bioavailability). Hence, the available read-across sediment toxicity data for alkyl phthalate esters surrogate such as DIDP, can help assess the potential toxicity of the submission terephthalate material (EC No. 416-740-6), especially in sediment invertebrates.
The read-across data for structurally related isomeric phthalate surrogate, namely, DIDP (CAS 68515 -49 -1) indicate that submission substance is not likely to produce toxicity to sediment dwellers at high sediment loadings (e.g., 3000 mg/kg). The sediment invertebrate dataset includes results for Chironomus tentans and Hyalella azteca
Reference: Call D et al. (2001). An assessment of the toxicity of phthalate esters to freshwater benthos. 2. Sediment expousres. Environ. Toxicol. Chem. 20(8): 1805 -1815.
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