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EC number: 200-935-6 | CAS number: 76-12-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- other: discussion based on literature data
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The source is considered reliable since reported information is based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- 1,1,2,2-TETRACHLORO-1,2-DIFLUOROETHANE
- Author:
- American Conference of Industrial Hygienists (ACGIH)
- Year:
- 2 008
- Bibliographic source:
- 1,1,2,2-Tetrachloro-1,2-Difluoroethane: TLV® Chemical Substances 7th Edition Documentation ACGIH® Publication
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 966
Materials and methods
- Principles of method if other than guideline:
- Discussion of literature data
- GLP compliance:
- not specified
- Test type:
- other: not documented
Test material
- Reference substance name:
- 1,1,2,2 -tetrachloro-1,2 –difluoroethane
- IUPAC Name:
- 1,1,2,2 -tetrachloro-1,2 –difluoroethane
- Reference substance name:
- Tetrachloro-1,2-difluoroethane
- EC Number:
- 200-935-6
- EC Name:
- Tetrachloro-1,2-difluoroethane
- Cas Number:
- 76-12-0
- Molecular formula:
- C2Cl4F2
- IUPAC Name:
- 1,1,2,2-tetrachloro-1,2-difluoroethane
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report):
1,1,2,2-tetrachloro-1,2-difluoroethane, CFC-112; 1,2-DIfluoro-1,1,2,2-tetrachloroethane; Halocarbon 112; Refrigerant 112
Constituent 1
Constituent 2
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- discriminating dose
- Effect level:
- > 7 500 mg/kg bw
- Based on:
- not specified
- Remarks on result:
- other: species. rabbit. (Clayton et al., 1966
Any other information on results incl. tables
According to the reference, no deaths were seen in rabbits following a dermal application of 7500 mg/kg bw to the skin.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- 1,1,2,2-tetrachloro-1,2-difluoroethane does not meet the Regulation (EC) No. 1272/2008 classification criteria for acute toxicity by dermal route.
- Executive summary:
The American Conference of Governmental Industrial Hygienists(ACGIH) is a professional association of industrial hygienists and practitioners of related professions. One of the goals of the association is to provide information and guideline on exposure limits of substances in order to advance worker protection.
ACGIH information is based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences.
The acute toxicity of 1,1,2,2-tetrachloro-1,2-difluoroethane by dermal route was assessed by ACGHI and to this purpose data deriving from scientific literature were rewieved.
No deaths were seen in rabbits following dermal application of 7500 mg/kg to the skin.
According to Regulation (EC) No. 1272/2008 the generic dose limit to classified a substance for dermal toxicity is LD50 = 2000 mg/kg.
Althougt the dose limit is based on the rat as preferred species to be tested under acute toxicity studies, the dose at which no deaths were seen in rabbit is well above the dose limit of 2000 mg/kg bw.
It can be concluded that no acute toxicity by dermal route is expected for 1,1,2,2-tetrachloro-1,2-difluoroethane, and therefore no classification is required according to Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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