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Diss Factsheets
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EC number: 482-120-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- UK GLP standards
- Type of study:
- other: local lymph node assay
Test material
- Details on test material:
- - Name of test material (as cited in study report): c-4000
- Physical state: liquid
- Analytical purity: >99%
- Purity test date: 2007-02-26
- Lot/batch No.: jyc0367
- Expiration date of the lot/batch: 2007-08-26
- Stability under test conditions: stable
- Storage condition of test material: room temperature and humidity
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
Study design: in vivo (LLNA)
- Vehicle:
- other: acetone/castor oil 4:1
- Concentration:
- 25% v/v test material in vehicle
50% v/v test material in vehicle
100% v/v test material in vehicle - No. of animals per dose:
- 5 animals received the vehicle
5 animals received a 25% v/v test material in vehicle
5 animals received a 50% v/v test material in vehicle
5 animals received a 100% v/v test material in vehicle
Results and discussion
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Remarks on result:
- other: A stimulation index of less than 3 (1.61 to 1.84) was recorded for the undiluted test material and test material diluted at 50 and 25% in vehicle.
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: Mean DPM reachs 2925 at the 50% dosage , compared to 1187 for control.
Any other information on results incl. tables
Table #: Results of LLNA: Mean Disintegrations per minute and stimulation index per group
Sample Description Test or Control Group |
Animal # |
Individual Animal |
Group Mean |
Stimulation Index (SI)* |
Vehicle |
1 |
|
1187.78 +/- 494.23 |
N\A |
2 |
|
|||
3 |
|
|||
4 |
|
|||
5 |
|
|||
25% |
1 |
|
1911.89 +/- 1911.89 |
1.61 |
2 |
|
|||
3 |
|
|||
4 |
|
|||
5 |
|
|||
50% |
1 |
|
2925.62 +/- 814.72 |
2.46 |
2 |
|
|||
3 |
|
|||
4 |
|
|||
5 |
|
|||
100% |
1 |
|
2187.72 +/- 711.64 |
1.84 |
2 |
|
|||
3 |
|
|||
4 |
|
|||
5 |
|
a) Pooled animal data is also acceptable (minimum of 4 animals/group)
* SI = Group mean DPM )Vehicle control mean DPM
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Conclusions:
- C-4000 is not a sensitizer and is not classified
- Executive summary:
In a dermal sensitization study with c-4000 (>99% a.i.) in acetone/olive oil 4:, BCBA/CA strain mouse females were tested using the method of the local lymph node assay. Positive control material is alpha-hexylcinnamaldehyde.Any signs of toxicity or sign of ill or bodyweight change was recorded during the test.
In this study, C-4000 is not a dermal sensitizer.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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