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EC number: 220-971-6 | CAS number: 2950-43-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Hydroxylamine-O-sulphonic acid
- EC Number:
- 220-971-6
- EC Name:
- Hydroxylamine-O-sulphonic acid
- Cas Number:
- 2950-43-8
- Molecular formula:
- H3NO4S
- IUPAC Name:
- (aminooxy)(hydroxy)sulfane dioxide
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Deutschland GmbH, Sandhofer Weg 7, 97633 Sulzfeld (Rat / Wistar / CrlGlxBrlHan:WI)
- Age at study initiation: Young adult animals (female animals approx. 14– 18 weeks)
- Weight at study initiation: Animals of comparable weight (200 - 204 grams)
- Fasting period before study: Feed was withdrawn from the animals at least 16 hours before administration, but water was available ad libitum
- Housing: Single housing
- Diet: Kliba-Labordiät (Maus / Ratte Haltung “GLP”), Provimi Kliba SA, Kaiseraugst, Basel, Switzerland, ad libitum
- Water: Tap water ad libitum
- Acclimation period: at least 5 days before administration
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24
- Humidity (%): 30 -70
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Olive oil Ph.Eur./DAB
- Details on oral exposure:
- - Amount of test material applied per gavage: 5.0 mL/kg bw
- Doses:
- 300, 500 and 2000 mg/kg bw
- No. of animals per sex per dose:
- 6 females at 300 mg/kg bw
3 females at 500 and 2000 mg/kg bw - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Individually after dosing at least once during the first 30 minutes, periodically during the first 24 hours, with special attention given during the first 4 hours, and daily thereafter; Individual weights of animals was determined shortly before the test substance was administered, and at least weekly thereafter
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology. - Statistics:
- Not mentioned.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 300 - < 500 mg/kg bw
- Based on:
- test mat.
- Mortality:
- - 300 mg/kg bw; 2. administration: 1/3 animals died after 7 days
- 300 mg/kg bw, 1. administration: No deaths occured until the end of the observation period on day 14
- 500 mg/kg bw: 1 animal died within 48 hours after administration, and one animal died after 7 days.
- 2000 mg/kg bw: 1 animal died within 1 hour after administration, and the two remaining died after 24 h. - Clinical signs:
- other: CLINICAL SIGNS: - 2000 mg/kg bw: impaired and poor general state, dyspnoea, abdominal position, staggering (h0 - h2) - 500 mg/kg bw: impaired and poor general state, dyspnoea, staggering, piloerection, smeared fur, exsiccosis, lacrimation, red or orange
- Gross pathology:
- Animals that died:
- 2000 mg/kg: glandular stomach: multifocal confluent black erosions/ulcers; kidneys, large and small intestine, lung: grey diffuse discoloration; liver: grey or black diffuse discoloration
- 500 mg/kg (2 animals): moderate or bad postmortal state; glandular stomach: few or many black erosions/ulcers, diameter up to 4 mm; stomach: moderate dilation with bloody contents
- 300 mg/kg (1 animal): bad postmortal state, organs without particular findings
Animals examined at the end of the observation period: 500 mg/kg, 1 female; 300 mg/kg, 5 females.
- Organs without particular findings.
Any other information on results incl. tables
Table 1: Summary of mortality data
Dose (mg/kg bw) |
number of dead animals (out of 3) after |
|
|||
|
1 h |
24 h |
48 h |
7 days |
14 days |
2000 |
1 |
3 |
3 |
3 |
3 |
500 |
0 |
0 |
1 |
2 |
2 |
300 (1 administration) |
0 |
0 |
0 |
0 |
0 |
300 (2 administrations) |
0 |
0 |
0 |
1 |
1 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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