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Diss Factsheets
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EC number: 700-351-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Biodegradation
The key study determined that the test item attained 1 % biodegradation after 28 days and therefore cannot be considered to be readily biodegradable (OECD 301 B, EU Method C.4 -C and CSPP 835.3110 (Paragraph (m)). A supporting study showed that biodegradation of the test substance was 10.7% after 28 days and, based on the residue analysis, biodegradation of the test substance was 8.00% during the testing period (HJ/T 153-2004, OECD 301 C and EU Method C.4-F).
Adsorption coefficient
The adsorption coefficient of the test item was determined to be in the range 42.8 to > 4.27 x 10E05 with a Log10 Pow of 1.63 to > 5.63 (OECD 121 and EU Method C.19).
Additional information
Biodegradation
A key study was performed to assess the ready biodegradability of the test item in an aerobic aqueous medium. The method followed was designed to be compatible with the OECD Guidelines for Testing of Chemicals (1992) No. 301B, "Ready Biodegradability; C02 Evolution Test" referenced as Method C.4-C of Commission Regulation (EC) No. 440/2008 and US EPA Fate, Transport, and Transformation Test Guidelines OCSPP 835.3110 (Paragraph (m)).
The test item, at a concentration of 10 mg carbon/L, was exposed to activated sewage sludge micro-organisms with mineral medium in sealed culture vessels in the dark at temperatures of between 18 to 24 °C for 28 days. Following the recommendations of the International Standards Organisation (ISO 1995), the test item was dissolved in an auxiliary solvent prior to being adsorbed onto a filter paper and subsequent dispersal in test media. Using this method the test item is evenly distributed throughout the test medium and the surface area of test item exposed to the test organisms is increased thereby increasing the potential for biodegradation. The biodegradation of the test item was assessed by the determination of carbon dioxide produced. Control solutions with inoculum and the reference item, sodium benzoate, together with a toxicity control were used for validation purposes.
The test item attained 1 % biodegradation after 28 days and therefore cannot be considered to be readily biodegradable under the strict terms and conditions of OECD Guideline No. 301B.
In a supporting study, the ready biodegradation test was performed according to “The guidelines for the testing of chemicals" (HJ/T 153-2004), “The guidelines for the testing of chemicals. Degradation and Accumulation'’ (the 2nd edition) (Beijing: China Environment Press. 2013), and Procedure 301 C of the ‘Guidelines for Testing of Chemicals’ of the OECD: “Modified MITI Test (I)” (1992) and EU Method C.4-F (Determination of the "Ready" Biodegradability - MITI Test).
The purpose of the test was to evaluate the ready biodegradability of organic chemicals via a 28- day test. The test substance and micro-organisms not adapted to the test substance were added to aerobic, aqueous medium in BOD bottles. The Biochemical Oxygen Demand (BOD) and residual chemicals in BOD bottles was then measured during the 28-day period. Test solutions were prepared in an inorganic salts medium, inoculated with a number of microorganisms collected from 10 places in Nanjing city. During the test, the temperature was kept at 25 ± 1 °C and pH was kept at 7.07 to 7.38. The total oxygen uptake in the inoculum blank was 30.0 mg 02/L at the end of the test, not exceeding 60 mg 02/L. The progress of degradation was followed by the determination BOD in the “test” and “blank control” vessels. Degradation was expressed as the ratio of the biochemical oxygen demand (BOD) and the theoretical oxygen demand (ThOD) in order to evaluate the ready biodegradability of chemical substance. The ready degradation rate was also expressed as percentage of initialconcentration of test substance, where the residue analysis of the test substance was performed at the end (28 d) of the test. Substances are considered to be “ready biodegradable” if the ready degradation rate is equal to or greater than 60% during the 28-day test period.
Biodegradation of the reference substance, sodium benzoate, reached 71.9% at 7 days (> 40%), and 83.6% at 14 days (> 65%). The difference of replicate values for inoculum blank and test, during the test, was both less than 20%. Biodegradation of inhibition control was 66.1% at 14 days (>25%), and oxygen consumption by the test substance was 37.6 mg 02/L (> 60% of inoculum blank), indicating that there was no inhibition effect to inoculum. Thus, the test was considered valid. The BOD results showed that biodegradation of the test substance was 10.7% after 28 days. Based on the residue analysis, biodegradation of the test substance was 8.00% during the testing period.
Adsorption / desorption coefficient (Koc)
The determination was carried out using the HPLC screening method, designed to be compatible with Method C.19 Adsorption Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 121 of the OECD Guidelines for Testing of Chemicals, 22 January 2001. The test utilised a High Performance Liquid Chromatograph. A commercially available cyanopropyl reverse phase HPLC column containing lipophilic and polar moieties was used. The adsorption coefficient of the test item was determined to be in the range 42.8 to > 4.27 x 10E05 with a Log10 Pow of 1.63 to > 5.63.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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