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EC number: 200-268-0 | CAS number: 56-35-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 18 October 1972 to 13 November 1972
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- A single per os application of ZK 21.955 was given to rats and observations were made.
- GLP compliance:
- no
- Remarks:
- Study was completed prior to GLP standards, but would have been substantially in compliance with GLP
- Limit test:
- no
Test material
- Reference substance name:
- Hexabutyldistannoxan
- IUPAC Name:
- Hexabutyldistannoxan
- Reference substance name:
- 21.955
- IUPAC Name:
- 21.955
- Details on test material:
- Supplied by Dr. Plum, Schering Bergkamen
Formulation: emulsion; 0.9 g NaCL + 0.5 g CMC + 0.085 g Myrj ad 100 ml dem. water, pH = 7
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- 30 male and 30 female rats, supplied by Dr. Hagemann.
Acclimatized for 9 days.
Caged in Macrolon type II with wire-mesh bottom, 1 animal per cage.
Body weight ranges from 75 to 105 grams for males, and 70 to 95 grams for females
Feed: pelleted Altrmomin R, ad libitum
Water: tap water, ad libitum
Room Temp = 22-24°C
Relative Humidity = 50-63 %
Fasting time prior to application:19 hours
Observation time: 27 days
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: CMC, NaCL, water
- Details on oral exposure:
- Per os (intragastrically); 1 gram in 100 ml
Formulation: Emulsion; 0.9 g NaCl + 0.5 g CMC + 0.085 g Myrj ad 100 mL dem. water (pH 7.0) - Doses:
- Single dose (1 gram in 100 ml)
- No. of animals per sex per dose:
- 30 male and 30 females (only one dose administered)
- Control animals:
- not specified
- Details on study design:
- No information
Results and discussion
- Preliminary study:
- No information
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 127 mg/kg bw
- 95% CL:
- >= 98 - <= 165
- Mortality:
- Yes - mortality occurred on day 2-6.
- Clinical signs:
- other: Apathy of dose-dependent degree, beginning at day 1 and lasting for several days, later on emaciation in single animals; extended abdomen, ruffled fur, paleness.
- Gross pathology:
- In animals dying before the end of the observation period, congestion, haemorrhages and hemorrhagic erosions of the gastric glandular mucosa, enteritis; haemorrhages, oedema, and emphysema of the lung (after 90 mg/kg and higher). In animals sacrificed at the end of the study, these effects were not seen.
Applicant's summary and conclusion
- Interpretation of results:
- other: Acute toxicity (category 3) according to EU criteria
- Conclusions:
- LD50 in rats (per os) = 127 mg/kg
confidence limit (95%): 98-165 mg/kg - Executive summary:
Animals received a single dose of test material, orally (by gavage) and observations were made. Apathy of dose-dependent degree, beginning at day 1 and lasting for several days, later on emaciation in single animals; extended abdomen, ruffled fur, paleness. Mortality occurred on day 2-6. In animals dying before the end of the observation period, congestion, hemorrhages and hemorrhagic erosions of the gastric glandular mucosa, enteritis; hemorrhages, edema, and emphysema of the lung (after 90 mg/kg and higher). In animals sacrificed at the end of the study, these effects were not seen.
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