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Diss Factsheets
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EC number: 287-401-6 | CAS number: 85507-79-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- before 22 February 1971
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Older study conducted prior to the introduction of GLP and OECD test guidelines. Standard methods used but details of methods and results not available. For read-across justification see Section 13.
Data source
Reference
- Reference Type:
- other: Diundecyl phthalate letter summary toxicity data
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Deviations:
- not specified
- Principles of method if other than guideline:
- Instillation of 0.1 ml of undiluted DUP into rabbit's eye. Observations scored at 1, 24 & 48h after instillation.
Probably FHSA test method used. - GLP compliance:
- no
Test material
- Reference substance name:
- Diundecyl phthalate
- EC Number:
- 222-884-9
- EC Name:
- Diundecyl phthalate
- Cas Number:
- 3648-20-2
- Molecular formula:
- C30H50O4
- IUPAC Name:
- diundecyl benzene-1,2-dicarboxylate
- Details on test material:
- Not reported
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Details on test animals or tissues and environmental conditions:
- Not reported
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.1 ml
- Duration of treatment / exposure:
- Single instillation followed by observation of effects for 48 hours
- Observation period (in vivo):
- 48H
- Number of animals or in vitro replicates:
- 6 based on no. of possible observations for conjunctival irritation
- Details on study design:
- Instillation of 0.1 ml of undiluted DUP in rabbit's eye. Observations scored at 1, 24 & 48h after instillation
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Basis:
- other: all animals
- Time point:
- other: 1h
- Score:
- 4
- Reversibility:
- fully reversible within: 48h
- Remarks on result:
- other: total score possible =110
- Irritation parameter:
- conjunctivae score
- Basis:
- other: all animals
- Time point:
- other: 24h
- Score:
- 3.3
- Reversibility:
- fully reversible within: 48h
- Remarks on result:
- other: total score possible =110
- Irritation parameter:
- conjunctivae score
- Basis:
- other: all animals
- Time point:
- other: 48
- Score:
- 0
- Reversibility:
- fully reversible
- Remarks:
- within 48h
- Remarks on result:
- other: total score possible = 110
- Irritation parameter:
- cornea opacity score
- Basis:
- other: all animals
- Time point:
- other: 1h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- cornea opacity score
- Basis:
- other: all animals
- Time point:
- other: 24h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- cornea opacity score
- Basis:
- other: all animals
- Time point:
- other: 48h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- other: all animals
- Time point:
- other: 1h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- other: all animals
- Time point:
- other: 24h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- other: all animals
- Time point:
- other: 48h
- Score:
- 0
- Max. score:
- 0
- Irritant / corrosive response data:
- minimal conjunctival irritation with a score of 4 out of a possible 110
- Other effects:
- Not reported
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Slight conjuctival irritation observed following exposure. Recovery within 48 hours
- Executive summary:
Slight conjuctival irritation observed following exposure. Recovery within 48 hours.
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