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EC number: 269-212-0 | CAS number: 68201-32-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2004-08-20 to 2004-09-19
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- GLP study performed according to Method 105 of the OECD Guidelines however; due to the complex nature of the test material no determination of water solubility was possible . No substance specific method of analysis could be obtained. During method development, the test material failed to dissolve in any solvent suitable for use with high performance liquid chromatography (HPLC) or gel permeation chromatography (GPC). Therefore, a visual and gravimetric assessment was used.
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No determination of water solubility was possible using Method 105 of the OECD Guidelines, due to the complex nature of the test material. No substance specific method of analysis could be obtained. During method development, the test material failed to dissolve in any solvent suitable for use with high performance liquid chromatography (HPLC) or gel permeation chromatography (GPC). Therefore, a visual and gravimetric assessment was used. The sponsor stated that the water solubility was 70% wt, a visual assessment to determine the approximate solubility was considered sufficient.
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- The Department of Health of the Government of the United Kingdom
- Type of method:
- flask method
- Water solubility:
- ca. 48.5 other: portion of test material soluble when prepared at approx. 5-10% w/w
- Temp.:
- 20 °C
- pH:
- 10
- Details on results:
- - Gravimetric analysis showed that approx. 48.5% of the test material as a whole was water-soluble at 20 +/- 0.5 deg C, when prepared at approx. 5-10% w/w.
- The percentage of test material that was soluble was calculated by the following equation:
% soluble = [(mean residue (% w/w)) / (prepared sample concentration (% w/w))] x 100 - Conclusions:
- No determination of water solubility was possible using method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995, due to the complex nature of the test material. However, using visual and gravimetric assessment, approx. 48.5% of the test material as a whole was found to be soluble at 20.0 +/- 0.5 degrees C at approx. 5 to 10% w/w. Visual assessment suggests that this will be the case at other prepared concentrations also.
- Executive summary:
N/A
Reference
Visual Assessment Results |
||
Sample Number |
Concentration (% w/w) |
Observations |
1 |
49.8 |
Very dark brown/black viscous solution. All test material wetted, but evidence of excess particulate material present. |
2 |
60.0 |
Very dark brown/black viscous solution. All test material wetted, but evidence of excess particulate material present, but sample immobile. Excess test material present. |
3 |
69.8 |
Very dark brown/black viscous solution. All test material wetted, but evidence of excess particulate material present, but small amount of powdery test material present. |
4 |
79.7 |
Much non-wetted test material present in excess. Small amount of wetted suspension/solution. |
5 |
89.9 |
Much non-wetted test material present in excess. Small amount of wetted suspension/solution. Much excess test material present. |
6 |
94.7 |
Much non-wetted test material present in excess. Small amount of wetted suspension/solution. Much excess test material present. |
7 |
5.00 |
Brown liquid with excess test material present. |
8 |
10.1 |
Brown liquid with excess test material present. |
9 |
20.1 |
Brown liquid with large amount of excess test material present. |
10 |
30.0 |
Brown liquid with large amount of excess test material present. |
11 |
39.9 |
Brown liquid with large amount of excess test material present. |
.
Calculated Percentage Residues for Each Sample |
||
Sample Number |
Percent Residue |
Mean Percent Residue |
1A |
2.41 |
2.44 |
1B |
2.47 |
|
2A |
4.82 |
4.84 |
2B |
4.86 |
.
Percentage of Test Material that was Soluble |
|||
Sample Number |
Prepared Sample Concentration (% w/w) |
Mean Residue (% w/w) |
Portion of Test Material Soluble (%) |
1 |
5.01 |
2.44 |
48.6 |
2 |
9.98 |
4.84 |
48.4 |
Description of key information
No determination of water solubility was possible using method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995, due to the complex nature of the test material. However, using visual and gravimetric assessment, approx. 48.5% of the test material as a whole was found to be soluble at 20.0 +/- 0.5 degrees C at approx. 5 to 10% w/w. Visual assessment suggests that this will be the case at other prepared concentrations also.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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