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EC number: 225-060-7 | CAS number: 4635-87-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Version / remarks:
- 1992
- Deviations:
- yes
- Remarks:
- Test item formulations not tested for stability, concentration and homogeneity. However, formulations preparations described in detail and visually inspected for homogeneity before use. All preparations used within 4 h after preparation.
- Qualifier:
- according to guideline
- Guideline:
- other: EC No 440/2008 Part B. Skin Sensitization: Buehler
- Version / remarks:
- May 2008
- Deviations:
- yes
- Remarks:
- Test item formulations not tested for stability, concentration and homogeneity. However, formulations preparations described in detail and visually inspected for homogeneity before use. All preparations used within 4 h after preparation.
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2600 (Skin Sensitisation)
- Version / remarks:
- March 2003
- Deviations:
- yes
- Remarks:
- Test item formulations not tested for stability, concentration and homogeneity. However, formulations preparations described in detail and visually inspected for homogeneity before use. All preparations used within 4 h after preparation.
- Qualifier:
- according to guideline
- Guideline:
- other: Appendix to Director General Notification, No. 12-Nousan-8147. Agricultural Production Bureau, Ministry of Agriculture, Forestry and Fisheries of Japan (JMAFF)
- Version / remarks:
- November 2000, including revisions up to 2019
- Deviations:
- yes
- Remarks:
- Test item formulations not tested for stability, concentration and homogeneity. However, formulations preparations described in detail and visually inspected for homogeneity before use. All preparations used within 4 h after preparation.
- GLP compliance:
- yes
- Type of study:
- Buehler test
- Justification for non-LLNA method:
- The guinea pig Buehler test was selected as the test item belongs to the nitrile class of
substances which are poorly predicted by the LLNA test. Initially the study was started as a Guinea pig Max.-test. This resulted in mortality and deterioration of animals directly after injection of the test solutions. The Buhler test could however be conducted. - Species:
- guinea pig
- Strain:
- Dunkin-Hartley
- Sex:
- female
- Route:
- epicutaneous, occlusive
- Vehicle:
- corn oil
- Concentration / amount:
- 50%
- Day(s)/duration:
- 6 h on day 1, 8 and 15
- Adequacy of induction:
- highest concentration used causing mild-to-moderate skin irritation and well-tolerated systemically
- Route:
- epicutaneous, occlusive
- Vehicle:
- corn oil
- Concentration / amount:
- 50%
- Day(s)/duration:
- 6h on day 28
- Adequacy of challenge:
- highest non-irritant concentration
- No. of animals per dose:
- 20 animals with 50% dose
- Challenge controls:
- 10 animals
- Positive control substance(s):
- no
- Remarks:
- ALPHA-HEXYLCINNAMALDEHYDE was used as periodic positive control
- Positive control results:
- 10/10 animals were positive after challenge (periodic control test)
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- positive control
- Dose level:
- 50%
- No. with + reactions:
- 10
- Total no. in group:
- 10
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- 0 %, only vehicle
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- no irritation after challenge
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- negative control
- Dose level:
- 0%, only vehicle
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- no irritation after challenge
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 50% in corn oil
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- No skin reactions were evident after the challenge exposure in the experimental and control
animals.
No mortality occurred and no symptoms of systemic toxicity were observed in the animals of
the main study. - Key result
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 50% in corn oil
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- Slight erythema and oedema were noted for the experimental animals during the induction
phase. No skin effects were noted for the controls.
No mortality occurred and no symptoms of systemic toxicity were observed in the animals of
the main study. - Interpretation of results:
- GHS criteria not met
- Conclusions:
- There was no evidence that 3-PENTENENITRILE had caused skin hypersensitivity in the
guinea pig, since no responses were observed in the experimental animals in response to a
50% test item concentration in the challenge phase.
This result indicates a sensitization rate of 0 per cent.
Based on these results 3-PENTENENITRILE does not have to be classified and has no
obligatory labelling requirement for sensitization by skin contact according to the Globally
Harmonized System of Classification and Labelling of Chemicals (GHS) of the United
Nations (2017) (including all amendments) and Regulation (EC) No 1272/2008 on
classification, labelling and packaging of items and mixtures (including all amendments).
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
Justification for classification or non-classification
3-Pentenenitrile is not classified as skin sensitizer according to the EU legislation (Directive 67/548/EEC and Regulation 1272/2008/EC).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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