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Diss Factsheets
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EC number: 902-591-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
PBT assessment
Administrative data
PBT assessment: overall result
- Name:
- Reaction Mass of Methyl Acetate and Methanol
- Type of composition:
- legal entity composition of the substance
- State / form:
- liquid
- Reference substance:
- Reaction Mass of Methyl Acetate and Methanol
- Reference substance:
- Reaction Mass of Methyl Acetate and Methanol
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Conclusion on P/vP: not P/vP
Based on a read across to the source substances Methanol and Methyl acetate the registration substance is considered to be readily biodegradable. The mean degradation rate of Methyl acetate based on oxygen was > 68% within the 10-day window and reached 70% at the end of the test period. Methanol is readily biodegradable in freshwater based on the results of standard ready tests that show 71.5 – 95 % removal after 5 and 20 days, respectively (please refer to IUCLID section 5.2.1). Thus, the registration substance is considered not P/vP according to the ECHA Guidance on Information Requirements and Safety Assessment, chapter R.11, PBT/vPvB assessment (version 3.0, June 2017).
Conclusion on B/vB: not B/vB
According to the ECHA Guidance on Information Requirements and Safety Assessment, chapter R.11, PBT/vPvB assessment (version 3.0, June 2017) the screening criterion for bioaccumulation potential for aquatic organisms is a Log Kow > 4.5. The screening criteria for bioaccumulation potential for air-breathing organisms are a Log Kow > 2 and a Log Koa > 5. Following an analogue read-across approach the Log Kow of the substance was determined to be 0.18 (please refer to IUCLID section 4.7). The Log Koa for the read across substance Methanol (CAS no. 67-56-1) is considered to be 2.880, for the read across substance Methyl acetate (CAS no. 79-20-9) 2.310 (KOAWIN v.1.10, experimental database). Hence, the screening criteria for bioaccumulation potential are not fulfiled and the registration substance is regarded to be non-bioaccumulative for aquatic and air-breathing organisms. Based on the chemical structure and physicochemical properties of the registration substance a non-lipophilic biocaccumulation is not expected. In conclusion, the registration substance is not B/vB.
Conclusion on T: T-criterion fulfilled
The lowest ecotoxicological long-term (chronic) effect value was determined based on a read-across approach to the structural analogue Methanol (CAS 67-56-1). The 21-day NOEC for Daphnia magna was found to be >100 mg/L (please refer to IUCLID section 6.1.4), which is clearly below the trigger value of EC10 or NOEC >= 0.01 for marine / freshwater organisms (long-term toxicity). Morover, the substance is not classified as carcinogenic, mutagenic or toxic to reproduction according to Directive 67/548/EEC or carcinogenic, germ cell mutagenic or toxic to reproduction according to Regulation EC No 1272/2008. However, the substance has to be classified STOT RE category 1 according to Regulation EC No 1272/2008. Therefore, the substance is regarded toxic (T) in compliance with above mentioned criteria and the ECHA Guidance on Information Requirements and Safety Assessment, chapter R.11, PBT/vPvB assessment (version 3.0, June 2017).
Overall conclusion on PBT/vPvB:
The substance is neither P/vP nor B/vB, but considered T. The substance is hence not PBT or vPvB in accordance with Regulation EC No 1907/2006 (REACH) and the ECHA Guidance on Information Requirements and Safety Assessment, chapter R.11, PBT/vPvB assessment (version 3.0, June 2017).
Reference
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.