Registration Dossier
Registration Dossier
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EC number: 205-124-0 | CAS number: 133-91-5
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro cytogenicity / chromosome aberration study in mammalian cells
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The inference is drawn from the read across chemicals based on grouping of substances on the basis of functional group and chemical elements (i.e.by category approach).On the basis of this category approach the substance was found to be 90-100% functional group similar.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- data obtained from prediction
- GLP compliance:
- not specified
- Type of assay:
- other: Salmonella-microsomal assay
Test material
- Reference substance name:
- Rafoxanide
- EC Number:
- 245-148-9
- EC Name:
- Rafoxanide
- Cas Number:
- 22662-39-1
- IUPAC Name:
- N-[3-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3,5-diiodobenzamide
- Details on test material:
- - Name of test material : rafoxanide
- Substance type: Organic
- Physical state: Solid
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- Chinese hamster Ovary (CHO)
- Additional strain / cell type characteristics:
- not applicable
- Metabolic activation:
- not specified
Results and discussion
Test results
- Species / strain:
- Chinese hamster Ovary (CHO)
- Metabolic activation:
- not specified
- Genotoxicity:
- not specified
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: other: no data
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
Based on the experimental data for in-vitro mammalian chromosome aberration test on Chinese hamster ovary (CHO) metabolic activation it was found that rafoxanide does not exhibit positive chromosomal effect. - Executive summary:
Based on the experimental data for in-vitro mammalian chromosome aberration test on Chinese hamster ovary (CHO) metabolic activation it was found that rafoxanide does not exhibit positive chromosomal effect.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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