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EC number: 267-140-4 | CAS number: 67801-20-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Ebanol will be classed as a slight skin and eye irritant.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Key Study for Skin Irritation In Vivo (Inveresk Research
International - 1985):
After 4 h exposure, very slight erythema (score 1) was noted in one
animal at 0.5 h and in all animals at 24 h. Moderate erythema (score 2)
was noted in 2 animals at 0.5 h. No oedema was noted in any animals.
Very slight to moderate irritant responses to Ebanol were noted. It is
concluded that after a 4 h exposure period, Ebanol is slightly
irritating to rabbit skin. All observed affects were fully reversible
within 48 hours.
Key Study for Eye Irritation In Vivo (Harlan Laboratories - 2010):
The test material produced a maximum group mean score of 12.0 and was classified as a mild irritant (Class 4 on a 1 to 8 scale) to the rabbit eye according to a modified Kay and Calandra classification system. Within 24 hours, mildly irritant. At 48 hours, minimal irritation. All observed affects were fully reversible within 72 hours.
Key Study for Eye Irritation In Vitro (Harlan Laboratories - 2010): Skinethic reconstituted human corneal epithelium
The Skinethic reconstituted human corneal epithelium model was administered 30µL of neat Ebanol for a 10 minute exposure period.
The optical density and viability data for the negative control and neat Ebanol (30µL) are: Negative control: OD540 = 0.923 and Viability = 100% ; Ebanol: OD540 = 0.921 and Viability = 99.8%. The test material Ebanol was considered to be a Non-Irritant.
Effects on skin irritation/corrosion: slightly irritating
Effects on eye irritation: slightly irritating
Justification for classification or non-classification
Based on the available in vivo skin irritancy study for Ebanol and the structurally related substance Polysantol used for read-across, in accordance with 67/548/and 1272/2008/EC, Ebanol is required to be labelled as a skin irritant.
Based on the available in vivo eye irritancy study for Ebanol, in accordance in accordance with 67/548/and 1272/2008/EC, Ebanol is required to be labelled as an eye irritant. Although the in vitro Skinethic reconstituted human corneal epithelium model gave a negative result for eye irritation, the in vivo study result takes precedence. In addition, in the in vivo study the cornea did not give significant affects which confirms the in vitro negative result. The in vivo significant effects were observed with the conjunctivae (redness, chemosis, discharge).
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