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EC number: 695-187-4 | CAS number: 166524-75-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in accordance with generally accepted scientific principles but with incomplete reporting. It is considered adequate for classification and labelling purposes.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 0.1 g of test material was administered into each conjunctival sac of a New Zealand White rabbit. One eye was washed after 30 seconds while the remaining eye was washed after one hour. The animal was observed for 7 days.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 5-ethoxy-2-({5-ethoxy-7-fluoro-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl}disulfanyl)-7-fluoro-[1,2,4]triazolo[1,5-c]pyrimidine
- EC Number:
- 695-187-4
- Cas Number:
- 166524-75-0
- Molecular formula:
- C14H12F2N8O2S2
- IUPAC Name:
- 5-ethoxy-2-({5-ethoxy-7-fluoro-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl}disulfanyl)-7-fluoro-[1,2,4]triazolo[1,5-c]pyrimidine
- Details on test material:
- - Name of test material (as cited in study report): 2,2'-Dithiobis(5-ethoxy-7-fluoro[1,2,4]triazolo[1,5-c]pyrimidine)
- Synonym: DEDS
- Appearance: light beige solid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 4.10 kg on day 1 of the study
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 g of test material per eye. - Duration of treatment / exposure:
- One eye was exposed for 30 seconds while the remaining eye was exposed for one hour.
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- One female
- Details on study design:
- ADMINISTRATION OF TEST SUBSTANCE
Ophthaine anaesthetic was administered to both eyes when the animal exhibited discomfort upon instillation of the test material into the first eye.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Yes, washed with water.
- Time after start of exposure: One eye was washed after a 30-second exposure while the other eye was washed after a one hour exposure.
Results and discussion
In vivo
- Irritant / corrosive response data:
- Slight conjunctival redness and swelling was observed immediately after dosing in the 30-second exposure eye. The hour exposure eye could not be observed due to the physical properties of the test material. One hour after dosing, both eyes had a slight conjunctival response, and both had very slight conjunctival response at 24 hours after dosing. The 30-second exposure eye was observed with very slight conjunctival response 48 and 72 hours after dosing.
Irritation in both eyes was resolved by test day seven and the test was terminated seven days after instillation. - Other effects:
- The animal survived the test period. No clinical signs indicative of systemic toxicity were observed. Bodyweight data are summarised in Table 1.
Any other information on results incl. tables
Table 1 Summary of Bodyweight Data (kg)
Animal Number |
Test Day |
|
1 |
4 |
|
93A5474 |
4.10 |
4.00 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Both eyes had a very slight conjunctival response at 24 hours after dosing. The 30-second exposure eye was observed with very slight conjunctival response 48 and 72 hours after dosing. Irritation in both eyes was resolved by test day seven.
Although the report does not include scoring of the effects observed there is sufficient information to conclude that classification of the substance as an eye irritant is not required. - Executive summary:
The potential of the test material to cause ocular irritation was investigated in the New Zealand White rabbit.
0.1 g of the test material was administered into each conjunctival sac of a female rabbit. One eye was washed after 30 seconds while the remaining eye was washed after one hour. The animal was observed for 7 days.
Slight conjunctival redness and swelling was observed immediately after dosing in the 30-second exposure eye. The hour exposure eye could not be observed due to the physical properties of the test material. One hour after dosing, both eyes had a slight conjunctival response, and both had very slight conjunctival response at 24 hours after dosing. The 30-second exposure eye was observed with very slight conjunctival response 48 and 72 hours after dosing.
Irritation in both eyes was resolved by test day seven and the test was terminated seven days after instillation. No clinical signs indicative of systemic toxicity were observed.
Although the report does not include scoring of the effects observed there is sufficient information to conclude that classification of the substance as an eye irritant is not required.
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