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EC number: 204-557-2 | CAS number: 122-60-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: human case study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only short communication available
Data source
Reference
- Reference Type:
- publication
- Title:
- Dermatitis from phenyl glycidyl ether
- Author:
- Rudzkii E, Rebandel P, Grzywa Z, Jakiminska B
- Year:
- 1 983
- Bibliographic source:
- Contact Dermatitis Vol 9 No 1, 90-91
Materials and methods
- Study type:
- clinical case study
- Endpoint addressed:
- skin sensitisation
- Principles of method if other than guideline:
- Case studies from 10 patients positive to phenyl glycidyl ether
- GLP compliance:
- not specified
Test material
- Reference substance name:
- phenyl glycidyl ether
- IUPAC Name:
- phenyl glycidyl ether
- Details on test material:
- - Name of test material: Phenyl glycidyl ether in 0.25 % alc
Constituent 1
Method
- Type of population:
- occupational
- Subjects:
- No exact data are available concerning either the work conditions of 8 of these patients or the course of their dermatitis. It is possible that epoxy resin was the primary sensitizer, and that phenyl glycidyl ether was a secondary allergen. In the other 2 patients the authors presume that phenyl glycidyl ether was the primary sensitizer.
- Ethical approval:
- not applicable
- Route of exposure:
- dermal
- Reason of exposure:
- intentional, occupational
- Exposure assessment:
- not specified
- Details on exposure:
- CASE 1: In 1968, a 34-year-old man started work as a laminater and came into contact with the following epoxy resins: (a) Epidian 5 Polish epoxy resin of bisphenol A type, molecular weight about 360; (b) Epidian 53 containing 90 % Epidian 5 and 10 %, styrene; (c) mixture of phenyl glycosidyl ether and Epidian 5 prepared freshly before use or within 12-24 h. He had used amounts of epoxy resin varying from 0.5 to 20 kg daily. In 1979 he became a joiner but continued to come into contact with epoxy glue which, however, did not contain phenyl glycidyl ether. In 1982, he was returning to his work as a laminater.
CASE 2: A 53-year-old man began to work in 1949 on the production of electric energy measuring instruments where epoxy resins have been used since 1969. At the beginning of 1972 he changed his work. Since March 1973 he has worked solely as a supervisor, with marked improvement but dermatitis recurred, therefore for the next 5 years ceased to have any contact with Epidian. From January 1980 to January 1982, he again supervised the production of electric energy measuring instruments and was in areas where Epidian 5 and phthalic anhydride were used. Because dermatitis appeared on his hands, forearms and face from this time on he ceased to have any contact with epoxy resin and its hardeners. When tested in March 1982, he was positive to epidian 5 and phenyl glycidyl ether (0.1 and 0.25 %) but negative to triethylenetetramine, phthalic anydride and the standard series. - Examinations:
- CASE 1: After working for 5 months under the conditions of epoxy resins, he developed dermatitis, at first on the forearms and soon after on the hands. The dermatitis fluctuated and recurred with the amount of resin used, and spread to the legs and face. When he becam a joiner in 1979, in this period, the skin changes almost completely disappeared. When he was seen in April 1982, there was no sign of dermatitis, and he was returning to his work as a laminater. He was patch test positive to phenyl glycidyl ether (0.25% alc.); the reaction to triethylenetetramine was doubtful. He was negative to the standard series and to 1% Epidian 5.
CASE 2: At the beginning of 1972, minimal dermatitis appeared on the skin on his hands but did not last long because he changed his work. After 2 months, he returned to working with epoxy resin. He himself mixed Epidian 5 with phenyl glycidyl ether. After 3 months, an acute dermatitis appeared on his hands and face. Nevertheless he continued to work, but used protective gloves and topical steroid creams, although minimal dermatitis persisted. In January 1974 he had a recurrence of dermatitis and for the next 5 years ceased to have any contact with Epidian, neither did he have any contact with phenyl glycidyl ether. In January 1982 he was obliged to undertake the work which he had previously supervised; a recurrent dermatitis appeared on the hands, forearms and face. From this time on he ceased to have any contact with epoxy resin and its hardeners. When tested in March 1982, he was positive to epidian 5 and phenyl glycidyl ether (0.1 and 0.25 %) but negative to triethylenetetramine, phthalic anydride and the standard series. - Medical treatment:
- CASE 2: protective gloves and topical steroid creams
Results and discussion
- Clinical signs:
- CASE 1: dermatitis, at first on the forearms and soon after on the hands.
CASE 2: dermatitis appeared on the skin, on his hands and on his face - Results of examinations:
- In both patients, dermatitis from phenyl glycidyl ether was diagnosed, since Case 1 was positive only to this compound and Case 2 was positive to it as well as to epoxy resin.
- Effectivity of medical treatment:
- CASE 2: although the man used protective gloves and topical steroid creams, minimal dermatitis persisted.
Applicant's summary and conclusion
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